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Ligand retargeting by binding site analogy.
Wiedmer L, Schärer C, Spiliotopoulos D, Hürzeler M, Śledź P, Caflisch A. Wiedmer L, et al. Eur J Med Chem. 2019 Aug 1;175:107-113. doi: 10.1016/j.ejmech.2019.04.037. Epub 2019 Apr 25. Eur J Med Chem. 2019. PMID: 31077996
METTL3 Inhibitors for Epitranscriptomic Modulation of Cellular Processes.
Moroz-Omori EV, Huang D, Kumar Bedi R, Cheriyamkunnel SJ, Bochenkova E, Dolbois A, Rzeczkowski MD, Li Y, Wiedmer L, Caflisch A. Moroz-Omori EV, et al. Among authors: wiedmer l. ChemMedChem. 2021 Oct 6;16(19):3035-3043. doi: 10.1002/cmdc.202100291. Epub 2021 Jul 29. ChemMedChem. 2021. PMID: 34237194 Free PMC article.
A Reader-Based Assay for m6A Writers and Erasers.
Wiedmer L, Eberle SA, Bedi RK, Śledź P, Caflisch A. Wiedmer L, et al. Anal Chem. 2019 Feb 19;91(4):3078-3084. doi: 10.1021/acs.analchem.8b05500. Epub 2019 Feb 4. Anal Chem. 2019. PMID: 30715855
Hitting a Moving Target: Simulation and Crystallography Study of ATAD2 Bromodomain Blockers.
Dolbois A, Batiste L, Wiedmer L, Dong J, Brütsch M, Huang D, Deerain NM, Spiliotopoulos D, Cheng-Sánchez I, Laul E, Nevado C, Śledź P, Caflisch A. Dolbois A, et al. Among authors: wiedmer l. ACS Med Chem Lett. 2020 Jun 30;11(8):1573-1580. doi: 10.1021/acsmedchemlett.0c00080. eCollection 2020 Aug 13. ACS Med Chem Lett. 2020. PMID: 32832026 Free PMC article.