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Oncogenic TYK2 P760L kinase is effectively targeted by combinatorial TYK2, mTOR and CDK4/6 kinase blockade.
Woess K, Macho-Maschler S, Van Ingen Schenau DS, Butler M, Lassnig C, Valcanover D, Poelzl A, Meissl K, Maurer B, Brandstoetter T, Vogl C, Koren A, Kubicek S, Orlova A, Moriggl R, Strobl B, Sexl V, Van Leeuwen FN, Kuiper RP, Mueller M. Woess K, et al. Among authors: lassnig c. Haematologica. 2023 Apr 1;108(4):993-1005. doi: 10.3324/haematol.2021.279848. Haematologica. 2023. PMID: 35021603 Free PMC article.
TYK2 kinase activity is required for functional type I interferon responses in vivo.
Prchal-Murphy M, Semper C, Lassnig C, Wallner B, Gausterer C, Teppner-Klymiuk I, Kobolak J, Müller S, Kolbe T, Karaghiosoff M, Dinnyés A, Rülicke T, Leitner NR, Strobl B, Müller M. Prchal-Murphy M, et al. Among authors: lassnig c. PLoS One. 2012;7(6):e39141. doi: 10.1371/journal.pone.0039141. Epub 2012 Jun 18. PLoS One. 2012. PMID: 22723949 Free PMC article.
Conditional ablation of TYK2 in immunity to viral infection and tumor surveillance.
Vielnascher RM, Hainzl E, Leitner NR, Rammerstorfer M, Popp D, Witalisz A, Rom R, Karaghiosoff M, Kolbe T, Müller S, Rülicke T, Lassnig C, Strobl B, Müller M. Vielnascher RM, et al. Among authors: lassnig c. Transgenic Res. 2014 Jun;23(3):519-29. doi: 10.1007/s11248-014-9795-y. Epub 2014 Apr 3. Transgenic Res. 2014. PMID: 24696087
STAT1β is not dominant negative and is capable of contributing to gamma interferon-dependent innate immunity.
Semper C, Leitner NR, Lassnig C, Parrini M, Mahlakõiv T, Rammerstorfer M, Lorenz K, Rigler D, Müller S, Kolbe T, Vogl C, Rülicke T, Staeheli P, Decker T, Müller M, Strobl B. Semper C, et al. Among authors: lassnig c. Mol Cell Biol. 2014 Jun;34(12):2235-48. doi: 10.1128/MCB.00295-14. Epub 2014 Apr 7. Mol Cell Biol. 2014. PMID: 24710278 Free PMC article.
Intestinal Epithelial Cell Tyrosine Kinase 2 Transduces IL-22 Signals To Protect from Acute Colitis.
Hainzl E, Stockinger S, Rauch I, Heider S, Berry D, Lassnig C, Schwab C, Rosebrock F, Milinovich G, Schlederer M, Wagner M, Schleper C, Loy A, Urich T, Kenner L, Han X, Decker T, Strobl B, Müller M. Hainzl E, et al. Among authors: lassnig c. J Immunol. 2015 Nov 15;195(10):5011-24. doi: 10.4049/jimmunol.1402565. Epub 2015 Oct 2. J Immunol. 2015. PMID: 26432894 Free PMC article.
The RNA helicase DDX3X is an essential mediator of innate antimicrobial immunity.
Szappanos D, Tschismarov R, Perlot T, Westermayer S, Fischer K, Platanitis E, Kallinger F, Novatchkova M, Lassnig C, Müller M, Sexl V, Bennett KL, Foong-Sobis M, Penninger JM, Decker T. Szappanos D, et al. Among authors: lassnig c. PLoS Pathog. 2018 Nov 26;14(11):e1007397. doi: 10.1371/journal.ppat.1007397. eCollection 2018 Nov. PLoS Pathog. 2018. PMID: 30475900 Free PMC article.
48 results