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Epicardial border zone overexpression of skeletal muscle sodium channel SkM1 normalizes activation, preserves conduction, and suppresses ventricular arrhythmia: an in silico, in vivo, in vitro study.
Lau DH, Clausen C, Sosunov EA, Shlapakova IN, Anyukhovsky EP, Danilo P Jr, Rosen TS, Kelly C, Duffy HS, Szabolcs MJ, Chen M, Robinson RB, Lu J, Kumari S, Cohen IS, Rosen MR. Lau DH, et al. Circulation. 2009 Jan 6;119(1):19-27. doi: 10.1161/CIRCULATIONAHA.108.809301. Epub 2008 Dec 22. Circulation. 2009. PMID: 19103989 Free PMC article.
Cardiac expression of skeletal muscle sodium channels increases longitudinal conduction velocity in the canine 1-week myocardial infarction.
Coronel R, Lau DH, Sosunov EA, Janse MJ, Danilo P Jr, Anyukhovsky EP, Wilms-Schopman FJ, Opthof T, Shlapakova IN, Ozgen N, Prestia K, Kryukova Y, Cohen IS, Robinson RB, Rosen MR. Coronel R, et al. Among authors: lau dh. Heart Rhythm. 2010 Aug;7(8):1104-10. doi: 10.1016/j.hrthm.2010.04.009. Epub 2010 Apr 10. Heart Rhythm. 2010. PMID: 20385252 Free PMC article.
SkM1 and Cx32 improve conduction in canine myocardial infarcts yet only SkM1 is antiarrhythmic.
Boink GJ, Lau DH, Shlapakova IN, Sosunov EA, Anyukhovsky EP, Driessen HE, Dun W, Chen M, Danilo P Jr, Rosen TS, Őzgen N, Duffy HS, Kryukova Y, Boyden PA, Robinson RB, Brink PR, Cohen IS, Rosen MR. Boink GJ, et al. Among authors: lau dh. Cardiovasc Res. 2012 Jun 1;94(3):450-9. doi: 10.1093/cvr/cvs107. Epub 2012 Feb 27. Cardiovasc Res. 2012. PMID: 22374989 Free PMC article.
Effect of skeletal muscle Na(+) channel delivered via a cell platform on cardiac conduction and arrhythmia induction.
Boink GJ, Lu J, Driessen HE, Duan L, Sosunov EA, Anyukhovsky EP, Shlapakova IN, Lau DH, Rosen TS, Danilo P, Jia Z, Ozgen N, Bobkov Y, Guo Y, Brink PR, Kryukova Y, Robinson RB, Entcheva E, Cohen IS, Rosen MR. Boink GJ, et al. Among authors: lau dh. Circ Arrhythm Electrophysiol. 2012 Aug 1;5(4):831-40. doi: 10.1161/CIRCEP.111.969907. Epub 2012 Jun 21. Circ Arrhythm Electrophysiol. 2012. PMID: 22722661 Free PMC article.
398 results