Laudon H - Search Results

1

A nine-transmembrane domain topology for presenilin 1.

Laudon H, Hansson EM, Melén K, Bergman A, Farmery MR, Winblad B, Lendahl U, von Heijne G, Näslund J. Laudon H, et al. J Biol Chem. 2005 Oct 21;280(42):35352-60. doi: 10.1074/jbc.M507217200. Epub 2005 Jul 25. J Biol Chem. 2005. PMID: 16046406 Free article.

2

APP intracellular domain formation and unaltered signaling in the presence of familial Alzheimer's disease mutations.

Bergman A, Religa D, Karlström H, Laudon H, Winblad B, Lannfelt L, Lundkvist J, Näslund J. Bergman A, et al. Among authors: laudon h. Exp Cell Res. 2003 Jul 1;287(1):1-9. doi: 10.1016/s0014-4827(03)00117-4. Exp Cell Res. 2003. PMID: 12799176

3

Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein.

Laudon H, Mathews PM, Karlström H, Bergman A, Farmery MR, Nixon RA, Winblad B, Gandy SE, Lendahl U, Lundkvist J, Näslund J. Laudon H, et al. J Neurochem. 2004 Apr;89(1):44-53. doi: 10.1046/j.1471-4159.2003.02298.x. J Neurochem. 2004. PMID: 15030388 Free article.

4

Functional domains in presenilin 1: the Tyr-288 residue controls gamma-secretase activity and endoproteolysis.

Laudon H, Karlström H, Mathews PM, Farmery MR, Gandy SE, Lundkvist J, Lendahl U, Näslund J. Laudon H, et al. J Biol Chem. 2004 Jun 4;279(23):23925-32. doi: 10.1074/jbc.M401277200. Epub 2004 Mar 29. J Biol Chem. 2004. PMID: 15051718 Free article.

5

The extreme C terminus of presenilin 1 is essential for gamma-secretase complex assembly and activity.

Bergman A, Laudon H, Winblad B, Lundkvist J, Näslund J. Bergman A, et al. Among authors: laudon h. J Biol Chem. 2004 Oct 29;279(44):45564-72. doi: 10.1074/jbc.M407717200. Epub 2004 Aug 20. J Biol Chem. 2004. PMID: 15322123 Free article.

6

gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity.

Strömberg K, Hansson EM, Laudon H, Bergstedt S, Näslund J, Lundkvist J, Lendahl U. Strömberg K, et al. Among authors: laudon h. J Neurochem. 2005 Nov;95(3):880-90. doi: 10.1111/j.1471-4159.2005.03415.x. Epub 2005 Aug 31. J Neurochem. 2005. PMID: 16135086 Free article.

7

The Alzheimer's disease-associated gamma-secretase complex: functional domains in the presenilin 1 protein.

Laudon H, Winblad B, Näslund J. Laudon H, et al. Physiol Behav. 2007 Sep 10;92(1-2):115-20. doi: 10.1016/j.physbeh.2007.05.037. Epub 2007 May 21. Physiol Behav. 2007. PMID: 17588625 Review.

8

The large hydrophilic loop of presenilin 1 is important for regulating gamma-secretase complex assembly and dictating the amyloid beta peptide (Abeta) Profile without affecting Notch processing.

Wanngren J, Frånberg J, Svensson AI, Laudon H, Olsson F, Winblad B, Liu F, Näslund J, Lundkvist J, Karlström H. Wanngren J, et al. Among authors: laudon h. J Biol Chem. 2010 Mar 19;285(12):8527-36. doi: 10.1074/jbc.M109.055590. Epub 2010 Jan 27. J Biol Chem. 2010. PMID: 20106965 Free PMC article.

9

Caspase cleaved presenilin-1 is part of active gamma-secretase complexes.

Hansson CA, Popescu BO, Laudon H, Cedazo-Minguez A, Popescu LM, Winblad B, Ankarcrona M. Hansson CA, et al. Among authors: laudon h. J Neurochem. 2006 Apr;97(2):356-64. doi: 10.1111/j.1471-4159.2006.03735.x. Epub 2006 Mar 15. J Neurochem. 2006. PMID: 16539675 Free article.

10

Amyloid beta pathology in Alzheimer's disease and schizophrenia.

Religa D, Laudon H, Styczynska M, Winblad B, Näslund J, Haroutunian V. Religa D, et al. Among authors: laudon h. Am J Psychiatry. 2003 May;160(5):867-72. doi: 10.1176/appi.ajp.160.5.867. Am J Psychiatry. 2003. PMID: 12727689

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