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ZN148 Is a Modular Synthetic Metallo-β-Lactamase Inhibitor That Reverses Carbapenem Resistance in Gram-Negative Pathogens In Vivo.
Samuelsen Ø, Åstrand OAH, Fröhlich C, Heikal A, Skagseth S, Carlsen TJO, Leiros HS, Bayer A, Schnaars C, Kildahl-Andersen G, Lauksund S, Finke S, Huber S, Gjøen T, Andresen AMS, Økstad OA, Rongved P. Samuelsen Ø, et al. Among authors: lauksund s. Antimicrob Agents Chemother. 2020 May 21;64(6):e02415-19. doi: 10.1128/AAC.02415-19. Print 2020 May 21. Antimicrob Agents Chemother. 2020. PMID: 32179522 Free PMC article.
Synthesis and Preclinical Evaluation of TPA-Based Zinc Chelators as Metallo-β-lactamase Inhibitors.
Schnaars C, Kildahl-Andersen G, Prandina A, Popal R, Radix S, Le Borgne M, Gjøen T, Andresen AMS, Heikal A, Økstad OA, Fröhlich C, Samuelsen Ø, Lauksund S, Jordheim LP, Rongved P, Åstrand OAH. Schnaars C, et al. Among authors: lauksund s. ACS Infect Dis. 2018 Sep 14;4(9):1407-1422. doi: 10.1021/acsinfecdis.8b00137. Epub 2018 Aug 2. ACS Infect Dis. 2018. PMID: 30022668
Synthesis and biological evaluation of zinc chelating compounds as metallo-β-lactamase inhibitors.
Kildahl-Andersen G, Schnaars C, Prandina A, Radix S, Le Borgne M, Jordheim LP, Gjøen T, Andresen AMS, Lauksund S, Fröhlich C, Samuelsen Ø, Rongved P, Åstrand OAH. Kildahl-Andersen G, et al. Among authors: lauksund s. Medchemcomm. 2019 Mar 8;10(4):528-537. doi: 10.1039/c8md00578h. eCollection 2019 Apr 1. Medchemcomm. 2019. PMID: 31057732 Free PMC article.
Amphipathic sulfonamidobenzamides mimicking small antimicrobial marine natural products; investigation of antibacterial and anti-biofilm activity against antibiotic resistant clinical isolates.
Igumnova EM, Mishchenko E, Haug T, Blencke HM, Sollid JUE, Fredheim EGA, Lauksund S, Stensvåg K, Strøm MB. Igumnova EM, et al. Among authors: lauksund s. Bioorg Med Chem. 2018 Sep 15;26(17):4930-4941. doi: 10.1016/j.bmc.2018.08.032. Epub 2018 Aug 28. Bioorg Med Chem. 2018. PMID: 30185388
Synthesis and antimicrobial activity of small cationic amphipathic aminobenzamide marine natural product mimics and evaluation of relevance against clinical isolates including ESBL-CARBA producing multi-resistant bacteria.
Igumnova EM, Mishchenko E, Haug T, Blencke HM, Sollid JUE, Fredheim EGA, Lauksund S, Stensvåg K, Strøm MB. Igumnova EM, et al. Among authors: lauksund s. Bioorg Med Chem. 2016 Nov 15;24(22):5884-5894. doi: 10.1016/j.bmc.2016.09.046. Epub 2016 Sep 20. Bioorg Med Chem. 2016. PMID: 27692769
RESTAMP - Rate estimates by sequence-tag analysis of microbial populations.
Mahmutovic A, Gillman AN, Lauksund S, Robson Moe NA, Manzi A, Storflor M, Abel Zur Wiesch P, Abel S. Mahmutovic A, et al. Among authors: lauksund s. Comput Struct Biotechnol J. 2021 Jan 19;19:1035-1051. doi: 10.1016/j.csbj.2021.01.017. eCollection 2021. Comput Struct Biotechnol J. 2021. PMID: 33613869 Free PMC article.
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