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RNA exploits an exposed regulatory site to inhibit the enzymatic activity of PRC2.
Zhang Q, McKenzie NJ, Warneford-Thomson R, Gail EH, Flanigan SF, Owen BM, Lauman R, Levina V, Garcia BA, Schittenhelm RB, Bonasio R, Davidovich C. Zhang Q, et al. Among authors: lauman r. Nat Struct Mol Biol. 2019 Mar;26(3):237-247. doi: 10.1038/s41594-019-0197-y. Epub 2019 Mar 4. Nat Struct Mol Biol. 2019. PMID: 30833789 Free PMC article.
Transcription factors interact with RNA to regulate genes.
Oksuz O, Henninger JE, Warneford-Thomson R, Zheng MM, Erb H, Vancura A, Overholt KJ, Hawken SW, Banani SF, Lauman R, Reich LN, Robertson AL, Hannett NM, Lee TI, Zon LI, Bonasio R, Young RA. Oksuz O, et al. Among authors: lauman r. Mol Cell. 2023 Jul 20;83(14):2449-2463.e13. doi: 10.1016/j.molcel.2023.06.012. Epub 2023 Jul 3. Mol Cell. 2023. PMID: 37402367
Regulation of eDHFR-tagged proteins with trimethoprim PROTACs.
Etersque JM, Lee IK, Sharma N, Xu K, Ruff A, Northrup JD, Sarkar S, Nguyen T, Lauman R, Burslem GM, Sellmyer MA. Etersque JM, et al. Among authors: lauman r. Nat Commun. 2023 Nov 3;14(1):7071. doi: 10.1038/s41467-023-42820-3. Nat Commun. 2023. PMID: 37923771 Free PMC article.