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α-Synuclein aggregation nucleates through liquid-liquid phase separation.
Ray S, Singh N, Kumar R, Patel K, Pandey S, Datta D, Mahato J, Panigrahi R, Navalkar A, Mehra S, Gadhe L, Chatterjee D, Sawner AS, Maiti S, Bhatia S, Gerez JA, Chowdhury A, Kumar A, Padinhateeri R, Riek R, Krishnamoorthy G, Maji SK. Ray S, et al. Among authors: gadhe l. Nat Chem. 2020 Aug;12(8):705-716. doi: 10.1038/s41557-020-0465-9. Epub 2020 Jun 8. Nat Chem. 2020. PMID: 32514159
Intermolecular interactions underlie protein/peptide phase separation irrespective of sequence and structure at crowded milieu.
Poudyal M, Patel K, Gadhe L, Sawner AS, Kadu P, Datta D, Mukherjee S, Ray S, Navalkar A, Maiti S, Chatterjee D, Devi J, Bera R, Gahlot N, Joseph J, Padinhateeri R, Maji SK. Poudyal M, et al. Among authors: gadhe l. Nat Commun. 2023 Oct 4;14(1):6199. doi: 10.1038/s41467-023-41864-9. Nat Commun. 2023. PMID: 37794023 Free PMC article.
Direct Demonstration of Seed Size-Dependent α-Synuclein Amyloid Amplification.
Sakunthala A, Datta D, Navalkar A, Gadhe L, Kadu P, Patel K, Mehra S, Kumar R, Chatterjee D, Devi J, Sengupta K, Padinhateeri R, Maji SK. Sakunthala A, et al. Among authors: gadhe l. J Phys Chem Lett. 2022 Jul 21;13(28):6427-6438. doi: 10.1021/acs.jpclett.2c01650. Epub 2022 Jul 11. J Phys Chem Lett. 2022. PMID: 35816132
18 results