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Enhanced synthesis of saturated phospholipids is associated with ER stress and lipotoxicity in palmitate treated hepatic cells.
J Lipid Res. 2014 Jul;55(7):1478-88. doi: 10.1194/jlr.M050237. Epub 2014 May 23.
J Lipid Res. 2014.
PMID: 24859739
Free PMC article.
Molecular mechanisms and the role of saturated fatty acids in the progression of non-alcoholic fatty liver disease.
Leamy AK, Egnatchik RA, Young JD.
Leamy AK, et al.
Prog Lipid Res. 2013 Jan;52(1):165-74. doi: 10.1016/j.plipres.2012.10.004. Epub 2012 Nov 23.
Prog Lipid Res. 2013.
PMID: 23178552
Free PMC article.
Review.
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Palmitate-induced activation of mitochondrial metabolism promotes oxidative stress and apoptosis in H4IIEC3 rat hepatocytes.
Egnatchik RA, Leamy AK, Noguchi Y, Shiota M, Young JD.
Egnatchik RA, et al. Among authors: leamy ak.
Metabolism. 2014 Feb;63(2):283-95. doi: 10.1016/j.metabol.2013.10.009. Epub 2013 Oct 24.
Metabolism. 2014.
PMID: 24286856
Free PMC article.
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ER calcium release promotes mitochondrial dysfunction and hepatic cell lipotoxicity in response to palmitate overload.
Egnatchik RA, Leamy AK, Jacobson DA, Shiota M, Young JD.
Egnatchik RA, et al. Among authors: leamy ak.
Mol Metab. 2014 May 22;3(5):544-53. doi: 10.1016/j.molmet.2014.05.004. eCollection 2014 Aug.
Mol Metab. 2014.
PMID: 25061559
Free PMC article.
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Knockdown of triglyceride synthesis does not enhance palmitate lipotoxicity or prevent oleate-mediated rescue in rat hepatocytes.
Leamy AK, Hasenour CM, Egnatchik RA, Trenary IA, Yao CH, Patti GJ, Shiota M, Young JD.
Leamy AK, et al.
Biochim Biophys Acta. 2016 Sep;1861(9 Pt A):1005-1014. doi: 10.1016/j.bbalip.2016.05.013. Epub 2016 May 29.
Biochim Biophys Acta. 2016.
PMID: 27249207
Free PMC article.
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Glutamate-oxaloacetate transaminase activity promotes palmitate lipotoxicity in rat hepatocytes by enhancing anaplerosis and citric acid cycle flux.
Egnatchik RA, Leamy AK, Sacco SA, Cheah YE, Shiota M, Young JD.
Egnatchik RA, et al. Among authors: leamy ak.
J Biol Chem. 2019 Mar 1;294(9):3081-3090. doi: 10.1074/jbc.RA118.004869. Epub 2018 Dec 18.
J Biol Chem. 2019.
PMID: 30563841
Free PMC article.
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