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Probes for narcotic receptor mediated phenomena. 34. Synthesis and structure-activity relationships of a potent mu-agonist delta-antagonist and an exceedingly potent antinociceptive in the enantiomeric C9-substituted 5-(3-hydroxyphenyl)-N-phenylethylmorphan series.
Hiebel AC, Lee YS, Bilsky E, Giuvelis D, Deschamps JR, Parrish DA, Aceto MD, May EL, Harris LS, Coop A, Dersch CM, Partilla JS, Rothman RB, Cheng K, Jacobson AE, Rice KC. Hiebel AC, et al. Among authors: lee ys. J Med Chem. 2007 Aug 9;50(16):3765-76. doi: 10.1021/jm061325e. Epub 2007 Jul 11. J Med Chem. 2007. PMID: 17625813
Probes for narcotic receptor mediated phenomena. 37. Synthesis and opioid binding affinity of the final pair of oxide-bridged phenylmorphans, the ortho- and para-b-isomers and their N-phenethyl analogues, and the synthesis of the N-phenethyl analogues of the ortho- and para-d-isomers.
Kurimura M, Liu H, Sulima A, Hashimoto A, Przybyl AK, Ohshima E, Kodato S, Deschamps JR, Dersch CM, Rothman RB, Lee YS, Jacobson AE, Rice KC. Kurimura M, et al. Among authors: lee ys. J Med Chem. 2008 Dec 25;51(24):7866-81. doi: 10.1021/jm800913d. J Med Chem. 2008. PMID: 19053757 Free PMC article.
8,237 results