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Redox regulation of proteasome function.
Lefaki M, Papaevgeniou N, Chondrogianni N. Lefaki M, et al. Redox Biol. 2017 Oct;13:452-458. doi: 10.1016/j.redox.2017.07.005. Epub 2017 Jul 6. Redox Biol. 2017. PMID: 28715730 Free PMC article. Review.
Proteasome activation delays aging in vitro and in vivo.
Chondrogianni N, Sakellari M, Lefaki M, Papaevgeniou N, Gonos ES. Chondrogianni N, et al. Among authors: lefaki m. Free Radic Biol Med. 2014 Jun;71:303-320. doi: 10.1016/j.freeradbiomed.2014.03.031. Epub 2014 Mar 27. Free Radic Biol Med. 2014. PMID: 24681338 Review.
2,3-Dehydrosilybin A/B as a pro-longevity and anti-aggregation compound.
Filippopoulou K, Papaevgeniou N, Lefaki M, Paraskevopoulou A, Biedermann D, Křen V, Chondrogianni N. Filippopoulou K, et al. Among authors: lefaki m. Free Radic Biol Med. 2017 Feb;103:256-267. doi: 10.1016/j.freeradbiomed.2016.12.042. Epub 2016 Dec 28. Free Radic Biol Med. 2017. PMID: 28039083
Protein ingestion preserves proteasome activity during intense aseptic inflammation and facilitates skeletal muscle recovery in humans.
Draganidis D, Chondrogianni N, Chatzinikolaou A, Terzis G, Karagounis LG, Sovatzidis A, Avloniti A, Lefaki M, Protopapa M, Deli CK, Papanikolaou K, Jamurtas AZ, Fatouros IG. Draganidis D, et al. Among authors: lefaki m. Br J Nutr. 2017 Aug;118(3):189-200. doi: 10.1017/S0007114517001829. Br J Nutr. 2017. PMID: 28831951 Clinical Trial.
Nuclear inclusions of pathogenic ataxin-1 induce oxidative stress and perturb the protein synthesis machinery.
Laidou S, Alanis-Lobato G, Pribyl J, Raskó T, Tichy B, Mikulasek K, Tsagiopoulou M, Oppelt J, Kastrinaki G, Lefaki M, Singh M, Zink A, Chondrogianni N, Psomopoulos F, Prigione A, Ivics Z, Pospisilova S, Skladal P, Izsvák Z, Andrade-Navarro MA, Petrakis S. Laidou S, et al. Among authors: lefaki m. Redox Biol. 2020 May;32:101458. doi: 10.1016/j.redox.2020.101458. Epub 2020 Feb 11. Redox Biol. 2020. PMID: 32145456 Free PMC article.
Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation.
Kelmer Sacramento E, Kirkpatrick JM, Mazzetto M, Baumgart M, Bartolome A, Di Sanzo S, Caterino C, Sanguanini M, Papaevgeniou N, Lefaki M, Childs D, Bagnoli S, Terzibasi Tozzini E, Di Fraia D, Romanov N, Sudmant PH, Huber W, Chondrogianni N, Vendruscolo M, Cellerino A, Ori A. Kelmer Sacramento E, et al. Among authors: lefaki m. Mol Syst Biol. 2020 Jun;16(6):e9596. doi: 10.15252/msb.20209596. Mol Syst Biol. 2020. PMID: 32558274 Free PMC article.
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