Legac J - Search Results

1

Extracts from Annona Muricata L. and Annona Reticulata L. (Annonaceae) Potently and Selectively Inhibit Plasmodium Falciparum.

Yamthe LRT, Fokou PVT, Mbouna CDJ, Keumoe R, Ndjakou BL, Djouonzo PT, Mfopa AN, Legac J, Tsabang N, Gut J, Rosenthal PJ, Boyom FF. Yamthe LRT, et al. Among authors: legac j. Medicines (Basel). 2015 Apr 30;2(2):55-66. doi: 10.3390/medicines2020055. Medicines (Basel). 2015. PMID: 28930201 Free PMC article.

2

Hemoglobin cleavage site-specificity of the Plasmodium falciparum cysteine proteases falcipain-2 and falcipain-3.

Subramanian S, Hardt M, Choe Y, Niles RK, Johansen EB, Legac J, Gut J, Kerr ID, Craik CS, Rosenthal PJ. Subramanian S, et al. Among authors: legac j. PLoS One. 2009;4(4):e5156. doi: 10.1371/journal.pone.0005156. Epub 2009 Apr 9. PLoS One. 2009. PMID: 19357776 Free PMC article.

3

Vinyl sulfones as antiparasitic agents and a structural basis for drug design.

Kerr ID, Lee JH, Farady CJ, Marion R, Rickert M, Sajid M, Pandey KC, Caffrey CR, Legac J, Hansell E, McKerrow JH, Craik CS, Rosenthal PJ, Brinen LS. Kerr ID, et al. Among authors: legac j. J Biol Chem. 2009 Sep 18;284(38):25697-703. doi: 10.1074/jbc.M109.014340. Epub 2009 Jul 20. J Biol Chem. 2009. PMID: 19620707 Free PMC article.

4

Falcipain inhibitors: optimization studies of the 2-pyrimidinecarbonitrile lead series.

Coterón JM, Catterick D, Castro J, Chaparro MJ, Díaz B, Fernández E, Ferrer S, Gamo FJ, Gordo M, Gut J, de las Heras L, Legac J, Marco M, Miguel J, Muñoz V, Porras E, de la Rosa JC, Ruiz JR, Sandoval E, Ventosa P, Rosenthal PJ, Fiandor JM. Coterón JM, et al. Among authors: legac j. J Med Chem. 2010 Aug 26;53(16):6129-52. doi: 10.1021/jm100556b. J Med Chem. 2010. PMID: 20672841

5

An image-based assay for high throughput screening of Giardia lamblia.

Gut J, Ang KK, Legac J, Arkin MR, Rosenthal PJ, McKerrow JH. Gut J, et al. Among authors: legac j. J Microbiol Methods. 2011 Mar;84(3):398-405. doi: 10.1016/j.mimet.2010.12.026. Epub 2011 Jan 22. J Microbiol Methods. 2011. PMID: 21262276

6

Identification of novel malarial cysteine protease inhibitors using structure-based virtual screening of a focused cysteine protease inhibitor library.

Shah F, Mukherjee P, Gut J, Legac J, Rosenthal PJ, Tekwani BL, Avery MA. Shah F, et al. Among authors: legac j. J Chem Inf Model. 2011 Apr 25;51(4):852-64. doi: 10.1021/ci200029y. Epub 2011 Mar 23. J Chem Inf Model. 2011. PMID: 21428453

7

Mining a cathepsin inhibitor library for new antiparasitic drug leads.

Ang KK, Ratnam J, Gut J, Legac J, Hansell E, Mackey ZB, Skrzypczynska KM, Debnath A, Engel JC, Rosenthal PJ, McKerrow JH, Arkin MR, Renslo AR. Ang KK, et al. Among authors: legac j. PLoS Negl Trop Dis. 2011 May 3;5(5):e1023. doi: 10.1371/journal.pntd.0001023. PLoS Negl Trop Dis. 2011. PMID: 21572521 Free PMC article.

8

Computer-aided drug design of falcipain inhibitors: virtual screening, structure-activity relationships, hydration site thermodynamics, and reactivity analysis.

Shah F, Gut J, Legac J, Shivakumar D, Sherman W, Rosenthal PJ, Avery MA. Shah F, et al. Among authors: legac j. J Chem Inf Model. 2012 Mar 26;52(3):696-710. doi: 10.1021/ci2005516. Epub 2012 Feb 28. J Chem Inf Model. 2012. PMID: 22332946

9

Compounds from Sorindeia juglandifolia (Anacardiaceae) exhibit potent anti-plasmodial activities in vitro and in vivo.

Kamkumo RG, Ngoutane AM, Tchokouaha LR, Fokou PV, Madiesse EA, Legac J, Kezetas JJ, Lenta BN, Boyom FF, Dimo T, Mbacham WF, Gut J, Rosenthal PJ. Kamkumo RG, et al. Among authors: legac j. Malar J. 2012 Nov 21;11:382. doi: 10.1186/1475-2875-11-382. Malar J. 2012. PMID: 23171238 Free PMC article.

10

Blocking Plasmodium falciparum development via dual inhibition of hemoglobin degradation and the ubiquitin proteasome system by MG132.

Prasad R, Atul, Kolla VK, Legac J, Singhal N, Navale R, Rosenthal PJ, Sijwali PS. Prasad R, et al. Among authors: legac j. PLoS One. 2013 Sep 2;8(9):e73530. doi: 10.1371/journal.pone.0073530. eCollection 2013. PLoS One. 2013. PMID: 24023882 Free PMC article.

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