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Page 1
Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human.
Ichimura A, Hirasawa A, Poulain-Godefroy O, Bonnefond A, Hara T, Yengo L, Kimura I, Leloire A, Liu N, Iida K, Choquet H, Besnard P, Lecoeur C, Vivequin S, Ayukawa K, Takeuchi M, Ozawa K, Tauber M, Maffeis C, Morandi A, Buzzetti R, Elliott P, Pouta A, Jarvelin MR, Körner A, Kiess W, Pigeyre M, Caiazzo R, Van Hul W, Van Gaal L, Horber F, Balkau B, Lévy-Marchal C, Rouskas K, Kouvatsi A, Hebebrand J, Hinney A, Scherag A, Pattou F, Meyre D, Koshimizu TA, Wolowczuk I, Tsujimoto G, Froguel P. Ichimura A, et al. Among authors: leloire a. Nature. 2012 Feb 19;483(7389):350-4. doi: 10.1038/nature10798. Nature. 2012. PMID: 22343897 Free article.
Tryptophan metabolism activation by indoleamine 2,3-dioxygenase in adipose tissue of obese women: an attempt to maintain immune homeostasis and vascular tone.
Wolowczuk I, Hennart B, Leloire A, Bessede A, Soichot M, Taront S, Caiazzo R, Raverdy V, Pigeyre M; ABOS Consortium; Guillemin GJ, Allorge D, Pattou F, Froguel P, Poulain-Godefroy O. Wolowczuk I, et al. Among authors: leloire a. Am J Physiol Regul Integr Comp Physiol. 2012 Jul 15;303(2):R135-43. doi: 10.1152/ajpregu.00373.2011. Epub 2012 May 16. Am J Physiol Regul Integr Comp Physiol. 2012. PMID: 22592557 Free article.
Contribution of the low-frequency, loss-of-function p.R270H mutation in FFAR4 (GPR120) to increased fasting plasma glucose levels.
Bonnefond A, Lamri A, Leloire A, Vaillant E, Roussel R, Lévy-Marchal C, Weill J, Galan P, Hercberg S, Ragot S, Hadjadj S, Charpentier G, Balkau B, Marre M, Fumeron F, Froguel P. Bonnefond A, et al. Among authors: leloire a. J Med Genet. 2015 Sep;52(9):595-8. doi: 10.1136/jmedgenet-2015-103065. Epub 2015 May 29. J Med Genet. 2015. PMID: 26025001
The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation.
Favennec M, Hennart B, Caiazzo R, Leloire A, Yengo L, Verbanck M, Arredouani A, Marre M, Pigeyre M, Bessede A, Guillemin GJ, Chinetti G, Staels B, Pattou F, Balkau B, Allorge D, Froguel P, Poulain-Godefroy O. Favennec M, et al. Among authors: leloire a. Obesity (Silver Spring). 2015 Oct;23(10):2066-74. doi: 10.1002/oby.21199. Epub 2015 Sep 8. Obesity (Silver Spring). 2015. PMID: 26347385 Free article.
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