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Nanoparticle-based modulation of CD4+ T cell effector and helper functions enhances adoptive immunotherapy.
Isser A, Silver AB, Pruitt HC, Mass M, Elias EH, Aihara G, Kang SS, Bachmann N, Chen YY, Leonard EK, Bieler JG, Chaisawangwong W, Choy J, Shannon SR, Gerecht S, Weber JS, Spangler JB, Schneck JP. Isser A, et al. Among authors: leonard ek. Nat Commun. 2022 Oct 14;13(1):6086. doi: 10.1038/s41467-022-33597-y. Nat Commun. 2022. PMID: 36241639 Free PMC article.
Engineered antibody fusion proteins for targeted disease therapy.
Silver AB, Leonard EK, Gould JR, Spangler JB. Silver AB, et al. Among authors: leonard ek. Trends Pharmacol Sci. 2021 Dec;42(12):1064-1081. doi: 10.1016/j.tips.2021.09.009. Epub 2021 Oct 25. Trends Pharmacol Sci. 2021. PMID: 34706833 Free PMC article. Review.
IgM anti-ACE2 autoantibodies in severe COVID-19 activate complement and perturb vascular endothelial function.
Casciola-Rosen L, Thiemann DR, Andrade F, Trejo-Zambrano MI, Leonard EK, Spangler JB, Skinner NE, Bailey J, Yegnasubramanian S, Wang R, Vaghasia AM, Gupta A, Cox AL, Ray SC, Linville RM, Guo Z, Searson PC, Machamer CE, Desiderio S, Sauer LM, Laeyendecker O, Garibaldi BT, Gao L, Damarla M, Hassoun PM, Hooper JE, Mecoli CA, Christopher-Stine L, Gutierrez-Alamillo L, Yang Q, Hines D, Clarke WA, Rothman RE, Pekosz A, Fenstermacher KZ, Wang Z, Zeger SL, Rosen A. Casciola-Rosen L, et al. Among authors: leonard ek. JCI Insight. 2022 May 9;7(9):e158362. doi: 10.1172/jci.insight.158362. JCI Insight. 2022. PMID: 35349483 Free PMC article.
In Vivo Stimulation of Therapeutic Antigen-Specific T Cells in an Artificial Lymph Node Matrix.
Livingston NK, Hickey JW, Sim H, Salathe SF, Choy J, Kong J, Silver AB, Stelzel JL, Omotoso MO, Li S, Chaisawangwong W, Roy S, Ariail EC, Lanis MR, Pradeep P, Bieler JG, Witte SE, Leonard E, Doloff JC, Spangler JB, Mao HQ, Schneck JP. Livingston NK, et al. Adv Mater. 2024 Feb 15:e2310043. doi: 10.1002/adma.202310043. Online ahead of print. Adv Mater. 2024. PMID: 38358310
IgM autoantibodies recognizing ACE2 are associated with severe COVID-19.
Casciola-Rosen L, Thiemann DR, Andrade F, Trejo Zambrano MI, Hooper JE, Leonard EK, Spangler JB, Cox AL, Machamer CE, Sauer L, Laeyendecker O, Garibaldi BT, Ray SC, Mecoli CA, Christopher-Stine L, Gutierrez-Alamillo L, Yang Q, Hines D, Clarke WA, Rothman R, Pekosz A, Fenstermacher KJ, Wang Z, Zeger SL, Rosen A. Casciola-Rosen L, et al. Among authors: leonard ek. medRxiv [Preprint]. 2020 Oct 15:2020.10.13.20211664. doi: 10.1101/2020.10.13.20211664. medRxiv. 2020. PMID: 33083808 Free PMC article. Updated. Preprint.
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