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Page 1
Cell-type-specific role for nucleus accumbens neuroligin-2 in depression and stress susceptibility.
Heshmati M, Aleyasin H, Menard C, Christoffel DJ, Flanigan ME, Pfau ML, Hodes GE, Lepack AE, Bicks LK, Takahashi A, Chandra R, Turecki G, Lobo MK, Maze I, Golden SA, Russo SJ. Heshmati M, et al. Among authors: lepack ae. Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):1111-1116. doi: 10.1073/pnas.1719014115. Epub 2018 Jan 16. Proc Natl Acad Sci U S A. 2018. PMID: 29339486 Free PMC article.
Aberrant H3.3 dynamics in NAc promote vulnerability to depressive-like behavior.
Lepack AE, Bagot RC, Peña CJ, Loh YE, Farrelly LA, Lu Y, Powell SK, Lorsch ZS, Issler O, Cates HM, Tamminga CA, Molina H, Shen L, Nestler EJ, Allis CD, Maze I. Lepack AE, et al. Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12562-12567. doi: 10.1073/pnas.1608270113. Epub 2016 Oct 18. Proc Natl Acad Sci U S A. 2016. PMID: 27791098 Free PMC article.
Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3.
Farrelly LA, Thompson RE, Zhao S, Lepack AE, Lyu Y, Bhanu NV, Zhang B, Loh YE, Ramakrishnan A, Vadodaria KC, Heard KJ, Erikson G, Nakadai T, Bastle RM, Lukasak BJ, Zebroski H 3rd, Alenina N, Bader M, Berton O, Roeder RG, Molina H, Gage FH, Shen L, Garcia BA, Li H, Muir TW, Maze I. Farrelly LA, et al. Among authors: lepack ae. Nature. 2019 Mar;567(7749):535-539. doi: 10.1038/s41586-019-1024-7. Epub 2019 Mar 13. Nature. 2019. PMID: 30867594 Free PMC article.
Stress resilience is promoted by a Zfp189-driven transcriptional network in prefrontal cortex.
Lorsch ZS, Hamilton PJ, Ramakrishnan A, Parise EM, Salery M, Wright WJ, Lepack AE, Mews P, Issler O, McKenzie A, Zhou X, Parise LF, Pirpinias ST, Ortiz Torres I, Kronman HG, Montgomery SE, Loh YE, Labonté B, Conkey A, Symonds AE, Neve RL, Turecki G, Maze I, Dong Y, Zhang B, Shen L, Bagot RC, Nestler EJ. Lorsch ZS, et al. Among authors: lepack ae. Nat Neurosci. 2019 Sep;22(9):1413-1423. doi: 10.1038/s41593-019-0462-8. Epub 2019 Aug 19. Nat Neurosci. 2019. PMID: 31427770 Free PMC article.
Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking.
Lepack AE, Werner CT, Stewart AF, Fulton SL, Zhong P, Farrelly LA, Smith ACW, Ramakrishnan A, Lyu Y, Bastle RM, Martin JA, Mitra S, O'Connor RM, Wang ZJ, Molina H, Turecki G, Shen L, Yan Z, Calipari ES, Dietz DM, Kenny PJ, Maze I. Lepack AE, et al. Science. 2020 Apr 10;368(6487):197-201. doi: 10.1126/science.aaw8806. Science. 2020. PMID: 32273471 Free PMC article.
Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn mouse model of Down syndrome.
Fulton SL, Wenderski W, Lepack AE, Eagle AL, Fanutza T, Bastle RM, Ramakrishnan A, Hays EC, Neal A, Bendl J, Farrelly LA, Al-Kachak A, Lyu Y, Cetin B, Chan JC, Tran TN, Neve RL, Roper RJ, Brennand KJ, Roussos P, Schimenti JC, Friedman AK, Shen L, Blitzer RD, Robison AJ, Crabtree GR, Maze I. Fulton SL, et al. Among authors: lepack ae. Nat Commun. 2022 Oct 26;13(1):6384. doi: 10.1038/s41467-022-34200-0. Nat Commun. 2022. PMID: 36289231 Free PMC article.
26 results