Lerch MT - Search Results

1

Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling.

Manglik A, Kim TH, Masureel M, Altenbach C, Yang Z, Hilger D, Lerch MT, Kobilka TS, Thian FS, Hubbell WL, Prosser RS, Kobilka BK. Manglik A, et al. Among authors: lerch mt. Cell. 2015 May 21;161(5):1101-1111. doi: 10.1016/j.cell.2015.04.043. Epub 2015 May 14. Cell. 2015. PMID: 25981665 Free PMC article.

2

Viewing rare conformations of the β₂ adrenergic receptor with pressure-resolved DEER spectroscopy.

Lerch MT, Matt RA, Masureel M, Elgeti M, Kumar KK, Hilger D, Foys B, Kobilka BK, Hubbell WL. Lerch MT, et al. Proc Natl Acad Sci U S A. 2020 Dec 15;117(50):31824-31831. doi: 10.1073/pnas.2013904117. Epub 2020 Nov 30. Proc Natl Acad Sci U S A. 2020. PMID: 33257561 Free PMC article.

3

Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations.

Wingler LM, Elgeti M, Hilger D, Latorraca NR, Lerch MT, Staus DP, Dror RO, Kobilka BK, Hubbell WL, Lefkowitz RJ. Wingler LM, et al. Among authors: lerch mt. Cell. 2019 Jan 24;176(3):468-478.e11. doi: 10.1016/j.cell.2018.12.005. Epub 2019 Jan 10. Cell. 2019. PMID: 30639099 Free PMC article.

4

Structural insights into differences in G protein activation by family A and family B GPCRs.

Hilger D, Kumar KK, Hu H, Pedersen MF, O'Brien ES, Giehm L, Jennings C, Eskici G, Inoue A, Lerch M, Mathiesen JM, Skiniotis G, Kobilka BK. Hilger D, et al. Science. 2020 Jul 31;369(6503):eaba3373. doi: 10.1126/science.aba3373. Science. 2020. PMID: 32732395 Free PMC article.

5

Circular dichroism and site-directed spin labeling reveal structural and dynamical features of high-pressure states of myoglobin.

Lerch MT, Horwitz J, McCoy J, Hubbell WL. Lerch MT, et al. Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):E4714-22. doi: 10.1073/pnas.1320124110. Epub 2013 Nov 18. Proc Natl Acad Sci U S A. 2013. PMID: 24248390 Free PMC article.

6

Mapping protein conformational heterogeneity under pressure with site-directed spin labeling and double electron-electron resonance.

Lerch MT, Yang Z, Brooks EK, Hubbell WL. Lerch MT, et al. Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):E1201-10. doi: 10.1073/pnas.1403179111. Epub 2014 Mar 18. Proc Natl Acad Sci U S A. 2014. PMID: 24707053 Free PMC article.

7

Structure-relaxation mechanism for the response of T4 lysozyme cavity mutants to hydrostatic pressure.

Lerch MT, López CJ, Yang Z, Kreitman MJ, Horwitz J, Hubbell WL. Lerch MT, et al. Proc Natl Acad Sci U S A. 2015 May 12;112(19):E2437-46. doi: 10.1073/pnas.1506505112. Epub 2015 Apr 27. Proc Natl Acad Sci U S A. 2015. PMID: 25918400 Free PMC article.

8

SIGNAL TRANSDUCTION. Structural basis for nucleotide exchange in heterotrimeric G proteins.

Dror RO, Mildorf TJ, Hilger D, Manglik A, Borhani DW, Arlow DH, Philippsen A, Villanueva N, Yang Z, Lerch MT, Hubbell WL, Kobilka BK, Sunahara RK, Shaw DE. Dror RO, et al. Among authors: lerch mt. Science. 2015 Jun 19;348(6241):1361-5. doi: 10.1126/science.aaa5264. Science. 2015. PMID: 26089515 Free PMC article.

9

Saturation Recovery EPR and Nitroxide Spin Labeling for Exploring Structure and Dynamics in Proteins.

Yang Z, Bridges M, Lerch MT, Altenbach C, Hubbell WL. Yang Z, et al. Among authors: lerch mt. Methods Enzymol. 2015;564:3-27. doi: 10.1016/bs.mie.2015.07.016. Epub 2015 Aug 15. Methods Enzymol. 2015. PMID: 26477246

10

High-Pressure EPR and Site-Directed Spin Labeling for Mapping Molecular Flexibility in Proteins.

Lerch MT, Yang Z, Altenbach C, Hubbell WL. Lerch MT, et al. Methods Enzymol. 2015;564:29-57. doi: 10.1016/bs.mie.2015.07.004. Epub 2015 Sep 9. Methods Enzymol. 2015. PMID: 26477247

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