Leu JI - Search Results

1

Functional interplay among thiol-based redox signaling, metabolism, and ferroptosis unveiled by a genetic variant of TP53.

Leu JI, Murphy ME, George DL. Leu JI, et al. Proc Natl Acad Sci U S A. 2020 Oct 27;117(43):26804-26811. doi: 10.1073/pnas.2009943117. Epub 2020 Oct 14. Proc Natl Acad Sci U S A. 2020. PMID: 33055209 Free PMC article.

2

The codon 72 polymorphic variants of p53 have markedly different apoptotic potential.

Dumont P, Leu JI, Della Pietra AC 3rd, George DL, Murphy M. Dumont P, et al. Among authors: leu ji. Nat Genet. 2003 Mar;33(3):357-65. doi: 10.1038/ng1093. Epub 2003 Feb 3. Nat Genet. 2003. PMID: 12567188

3

Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.

Leu JI, Dumont P, Hafey M, Murphy ME, George DL. Leu JI, et al. Nat Cell Biol. 2004 May;6(5):443-50. doi: 10.1038/ncb1123. Epub 2004 Apr 11. Nat Cell Biol. 2004. PMID: 15077116

4

p53 moves to mitochondria: a turn on the path to apoptosis.

Murphy ME, Leu JI, George DL. Murphy ME, et al. Among authors: leu ji. Cell Cycle. 2004 Jul;3(7):836-9. Epub 2004 Jul 4. Cell Cycle. 2004. PMID: 15190209 Review.

5

The tetramerization domain of p53 is required for efficient BAK oligomerization.

Pietsch EC, Leu JI, Frank A, Dumont P, George DL, Murphy ME. Pietsch EC, et al. Among authors: leu ji. Cancer Biol Ther. 2007 Oct;6(10):1576-83. doi: 10.4161/cbt.6.10.4719. Epub 2007 Jul 10. Cancer Biol Ther. 2007. PMID: 17895645

6

Hepatic IGFBP1 is a prosurvival factor that binds to BAK, protects the liver from apoptosis, and antagonizes the proapoptotic actions of p53 at mitochondria.

Leu JI, George DL. Leu JI, et al. Genes Dev. 2007 Dec 1;21(23):3095-109. doi: 10.1101/gad.1567107. Genes Dev. 2007. PMID: 18056423 Free PMC article.

7

A small molecule inhibitor of inducible heat shock protein 70.

Leu JI, Pimkina J, Frank A, Murphy ME, George DL. Leu JI, et al. Mol Cell. 2009 Oct 9;36(1):15-27. doi: 10.1016/j.molcel.2009.09.023. Mol Cell. 2009. PMID: 19818706 Free PMC article.

8

The codon 72 polymorphism of p53 regulates interaction with NF-{kappa}B and transactivation of genes involved in immunity and inflammation.

Frank AK, Leu JI, Zhou Y, Devarajan K, Nedelko T, Klein-Szanto A, Hollstein M, Murphy ME. Frank AK, et al. Among authors: leu ji. Mol Cell Biol. 2011 Mar;31(6):1201-13. doi: 10.1128/MCB.01136-10. Epub 2011 Jan 18. Mol Cell Biol. 2011. PMID: 21245379 Free PMC article.

9

HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells.

Leu JI, Pimkina J, Pandey P, Murphy ME, George DL. Leu JI, et al. Mol Cancer Res. 2011 Jul;9(7):936-47. doi: 10.1158/1541-7786.MCR-11-0019. Epub 2011 Jun 2. Mol Cancer Res. 2011. PMID: 21636681 Free PMC article.

10

A modified HSP70 inhibitor shows broad activity as an anticancer agent.

Balaburski GM, Leu JI, Beeharry N, Hayik S, Andrake MD, Zhang G, Herlyn M, Villanueva J, Dunbrack RL Jr, Yen T, George DL, Murphy ME. Balaburski GM, et al. Among authors: leu ji. Mol Cancer Res. 2013 Mar;11(3):219-29. doi: 10.1158/1541-7786.MCR-12-0547-T. Epub 2013 Jan 9. Mol Cancer Res. 2013. PMID: 23303345 Free PMC article.

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