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Fishing for allosteric sites on GABA(A) receptors.
Olsen RW, Chang CS, Li G, Hanchar HJ, Wallner M. Olsen RW, et al. Among authors: li g. Biochem Pharmacol. 2004 Oct 15;68(8):1675-84. doi: 10.1016/j.bcp.2004.07.026. Biochem Pharmacol. 2004. PMID: 15451411
Neurosteroids allosterically modulate binding of the anesthetic etomidate to gamma-aminobutyric acid type A receptors.
Li GD, Chiara DC, Cohen JB, Olsen RW. Li GD, et al. J Biol Chem. 2009 May 1;284(18):11771-5. doi: 10.1074/jbc.C900016200. Epub 2009 Mar 12. J Biol Chem. 2009. PMID: 19282280 Free PMC article.
We tested whether the two ligand binding sites might overlap by examining whether neuroactive steroids inhibited etomidate analog photolabeling. We previously identified (Li, G. D., Chiara, D. C., Sawyer, G. W., Husain, S. S., Olsen, R. ...Thus modulatory ste …
We tested whether the two ligand binding sites might overlap by examining whether neuroactive steroids inhibited etomidate analog photolabel …
Numerous classes of general anesthetics inhibit etomidate binding to gamma-aminobutyric acid type A (GABAA) receptors.
Li GD, Chiara DC, Cohen JB, Olsen RW. Li GD, et al. J Biol Chem. 2010 Mar 19;285(12):8615-20. doi: 10.1074/jbc.M109.074708. Epub 2010 Jan 18. J Biol Chem. 2010. PMID: 20083606 Free PMC article.
The implied existence of a receptor site for anesthetics on the GABA(A)R protein was supported by identification, using photoaffinity labeling, of a binding site for etomidate within the GABA(A)R transmembrane domain at the beta-alpha subunit interface; the etomidate analog [(3)H …
The implied existence of a receptor site for anesthetics on the GABA(A)R protein was supported by identification, using photoaffinity labeli …
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