Neurosteroids allosterically modulate binding of the anesthetic etomidate to gamma-aminobutyric acid type A receptors.
Li GD, Chiara DC, Cohen JB, Olsen RW.
Li GD, et al.
J Biol Chem. 2009 May 1;284(18):11771-5. doi: 10.1074/jbc.C900016200. Epub 2009 Mar 12.
J Biol Chem. 2009.
PMID: 19282280
Free PMC article.
We tested whether the two ligand binding sites might overlap by examining whether neuroactive steroids inhibited etomidate analog photolabeling. We previously identified (Li, G. D., Chiara, D. C., Sawyer, G. W., Husain, S. S., Olsen, R. ...Thus modulatory ste …
We tested whether the two ligand binding sites might overlap by examining whether neuroactive steroids inhibited etomidate analog photolabel …