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Co-expression of a PD-L1-specific chimeric switch receptor augments the efficacy and persistence of CAR T cells via the CD70-CD27 axis.
Qin L, Cui Y, Yuan T, Chen D, Zhao R, Li S, Jiang Z, Wu Q, Long Y, Wang S, Tang Z, Pan H, Li X, Wei W, Yang J, Luo X, Zhang Z, Tang Q, Liu P, Weinkove R, Yao Y, Qin D, Thiery JP, Li P. Qin L, et al. Among authors: li s, li x, li p. Nat Commun. 2022 Oct 13;13(1):6051. doi: 10.1038/s41467-022-33793-w. Nat Commun. 2022. PMID: 36229619 Free PMC article.
IL-6 trans-signaling promotes the expansion and anti-tumor activity of CAR T cells.
Jiang Z, Liao R, Lv J, Li S, Zheng D, Qin L, Wu D, Chen S, Long Y, Wu Q, Wang S, Lin S, Huang X, Tang Z, Shi P, Zhou H, Liu Q, Zhao R, Li Y, Jie Y, Wei W, Lai P, Du X, Cui S, Weinkove R, Liu P, Pei D, Yao Y, Li P. Jiang Z, et al. Among authors: li s, li y, li p. Leukemia. 2021 May;35(5):1380-1391. doi: 10.1038/s41375-020-01085-1. Epub 2020 Nov 9. Leukemia. 2021. PMID: 33168950
Human induced-T-to-natural killer cells have potent anti-tumour activities.
Jiang Z, Qin L, Tang Y, Liao R, Shi J, He B, Li S, Zheng D, Cui Y, Wu Q, Long Y, Yao Y, Wei Z, Hong Q, Wu Y, Mai Y, Gou S, Li X, Weinkove R, Norton S, Luo W, Feng W, Zhou H, Liu Q, Chen J, Lai L, Chen X, Pei D, Graf T, Liu X, Li Y, Liu P, Zhang Z, Li P. Jiang Z, et al. Among authors: li s, li y, li x, li p. Biomark Res. 2022 Mar 24;10(1):13. doi: 10.1186/s40364-022-00358-4. Biomark Res. 2022. PMID: 35331335 Free PMC article.
Current status and hurdles for CAR-T cell immune therapy.
Zhao R, Cui Y, Li S, Qin L, Li P. Zhao R, et al. Among authors: li s, li p. Blood Sci. 2019 Oct 21;1(2):148-155. doi: 10.1097/BS9.0000000000000025. eCollection 2019 Oct. Blood Sci. 2019. PMID: 35402809 Free PMC article.
DAP10 integration in CAR-T cells enhances the killing of heterogeneous tumors by harnessing endogenous NKG2D.
Li S, Zhao R, Zheng D, Qin L, Cui Y, Li Y, Jiang Z, Zhong M, Shi J, Li M, Wang X, Tang Z, Wu Q, Long Y, Hu D, Wang S, Yao Y, Liu S, Yang LH, Zhang Z, Tang Q, Liu P, Li Y, Li P. Li S, et al. Among authors: li y, li m, li p. Mol Ther Oncolytics. 2022 Jun 6;26:15-26. doi: 10.1016/j.omto.2022.06.003. eCollection 2022 Sep 15. Mol Ther Oncolytics. 2022. PMID: 35784403 Free PMC article.
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