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Misfolded proinsulin impairs processing of precursor of insulin receptor and insulin signaling in β cells.
Liu S, Li X, Yang J, Zhu R, Fan Z, Xu X, Feng W, Cui J, Sun J, Liu M. Liu S, et al. Among authors: li x. FASEB J. 2019 Oct;33(10):11338-11348. doi: 10.1096/fj.201900442R. Epub 2019 Aug 1. FASEB J. 2019. PMID: 31311313 Free PMC article.
These results reveal for the first time that misfolded proinsulin can interact with ProIR in the ER, impairing intracellular processing of ProIR and leading to defective insulin signaling that may contribute to beta-cell failure in both MIDY and T2D.-Liu, S., Li, X. …
These results reveal for the first time that misfolded proinsulin can interact with ProIR in the ER, impairing intracellular processing of P …
IER3IP1 is critical for maintaining glucose homeostasis through regulating the endoplasmic reticulum function and survival of β cells.
Yang J, Zhen J, Feng W, Fan Z, Ding L, Yang X, Huang Y, Shu H, Xie J, Li X, Qiao J, Fan Y, Sun J, Li N, Liu T, Wang S, Zhang X, Arvan P, Liu M. Yang J, et al. Among authors: li x, li n. Proc Natl Acad Sci U S A. 2022 Nov 8;119(45):e2204443119. doi: 10.1073/pnas.2204443119. Epub 2022 Nov 2. Proc Natl Acad Sci U S A. 2022. PMID: 36322741 Free PMC article.
Gender- and Age-Specific Differences in the Association of Hyperuricemia and Hypertension: A Cross-Sectional Study.
Lin X, Wang X, Li X, Song L, Meng Z, Yang Q, Zhang W, Gao Y, Yang Z, Cai H, Bian B, Li Y, Yu X, Du X, Xu S, Nie J, Liu M, Sun J, Zhang Q, Gao Y, Song K, Wang X, Zhao L, Fan Y. Lin X, et al. Among authors: li y, li x. Int J Endocrinol. 2019 Feb 28;2019:7545137. doi: 10.1155/2019/7545137. eCollection 2019. Int J Endocrinol. 2019. PMID: 30944567 Free PMC article.
167,949 results
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