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The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK.
Zhang CS, Li M, Wang Y, Li X, Zong Y, Long S, Zhang M, Feng JW, Wei X, Liu YH, Zhang B, Wu J, Zhang C, Lian W, Ma T, Tian X, Qu Q, Yu Y, Xiong J, Liu DT, Wu Z, Zhu M, Xie C, Wu Y, Xu Z, Yang C, Chen J, Huang G, He Q, Huang X, Zhang L, Sun X, Liu Q, Ghafoor A, Gui F, Zheng K, Wang W, Wang ZC, Yu Y, Zhao Q, Lin SY, Wang ZX, Piao HL, Deng X, Lin SC. Zhang CS, et al. Among authors: lian w. Nat Metab. 2022 Oct;4(10):1369-1401. doi: 10.1038/s42255-022-00640-7. Epub 2022 Oct 10. Nat Metab. 2022. PMID: 36217034 Free PMC article.
Pharmacological Targeting of Vacuolar H+-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer.
Wang Y, Zhang L, Wei Y, Huang W, Li L, Wu AA, Dastur A, Greninger P, Bray WM, Zhang CS, Li M, Lian W, Hu Z, Wang X, Liu G, Yao L, Guh JH, Chen L, Wang HR, Zhou D, Lin SC, Xu Q, Shen Y, Zhang J, Jurica MS, Benes CH, Deng X. Wang Y, et al. Among authors: lian w. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9. Cell Chem Biol. 2020. PMID: 32649904 Free article.
Discovery of 4-methyl-N-(4-((4-methylpiperazin- 1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-oxy)benzamide as a potent inhibitor of RET and its gatekeeper mutant.
Li X, Su J, Yang Y, Lian W, Deng Z, Yang Z, Chen G, Zhang B, Dong C, Liu X, Li L, Wang Z, Hu Z, Xu Q, Deng X. Li X, et al. Among authors: lian w. Eur J Med Chem. 2020 Dec 1;207:112755. doi: 10.1016/j.ejmech.2020.112755. Epub 2020 Aug 22. Eur J Med Chem. 2020. PMID: 32882611
Hierarchical structured and programmed vehicles deliver drugs locally to inflamed sites of intestine.
Li W, Li Y, Liu Z, Kerdsakundee N, Zhang M, Zhang F, Liu X, Bauleth-Ramos T, Lian W, Mäkilä E, Kemell M, Ding Y, Sarmento B, Wiwattanapatapee R, Salonen J, Zhang H, Hirvonen JT, Liu D, Deng X, Santos HA. Li W, et al. Among authors: lian w. Biomaterials. 2018 Dec;185:322-332. doi: 10.1016/j.biomaterials.2018.09.024. Epub 2018 Sep 19. Biomaterials. 2018. PMID: 30267958 Free article.
Tandem-Mass-Tag Based Proteomic Analysis Facilitates Analyzing Critical Factors of Porous Silicon Nanoparticles in Determining Their Biological Responses under Diseased Condition.
Li Y, Liu Z, Li L, Lian W, He Y, Khalil E, Mäkilä E, Zhang W, Torrieri G, Liu X, Su J, Xiu Y, Fontana F, Salonen J, Hirvonen J, Liu W, Zhang H, Santos HA, Deng X. Li Y, et al. Among authors: lian w. Adv Sci (Weinh). 2020 Jun 23;7(15):2001129. doi: 10.1002/advs.202001129. eCollection 2020 Aug. Adv Sci (Weinh). 2020. PMID: 32775170 Free PMC article.
738 results