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Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice.
Birkenfeld AL, Lee HY, Guebre-Egziabher F, Alves TC, Jurczak MJ, Jornayvaz FR, Zhang D, Hsiao JJ, Martin-Montalvo A, Fischer-Rosinsky A, Spranger J, Pfeiffer AF, Jordan J, Fromm MF, König J, Lieske S, Carmean CM, Frederick DW, Weismann D, Knauf F, Irusta PM, De Cabo R, Helfand SL, Samuel VT, Shulman GI. Birkenfeld AL, et al. Among authors: lieske s. Cell Metab. 2011 Aug 3;14(2):184-95. doi: 10.1016/j.cmet.2011.06.009. Cell Metab. 2011. PMID: 21803289 Free PMC article.
The human longevity gene homolog INDY and interleukin-6 interact in hepatic lipid metabolism.
von Loeffelholz C, Lieske S, Neuschäfer-Rube F, Willmes DM, Raschzok N, Sauer IM, König J, Fromm MF, Horn P, Chatzigeorgiou A, Pathe-Neuschäfer-Rube A, Jordan J, Pfeiffer AFH, Mingrone G, Bornstein SR, Stroehle P, Harms C, Wunderlich FT, Helfand SL, Bernier M, de Cabo R, Shulman GI, Chavakis T, Püschel GP, Birkenfeld AL. von Loeffelholz C, et al. Among authors: lieske s. Hepatology. 2017 Aug;66(2):616-630. doi: 10.1002/hep.29089. Epub 2017 Jun 26. Hepatology. 2017. PMID: 28133767 Free PMC article.
Influence of the hepatic eukaryotic initiation factor 2alpha (eIF2alpha) endoplasmic reticulum (ER) stress response pathway on insulin-mediated ER stress and hepatic and peripheral glucose metabolism.
Birkenfeld AL, Lee HY, Majumdar S, Jurczak MJ, Camporez JP, Jornayvaz FR, Frederick DW, Guigni B, Kahn M, Zhang D, Weismann D, Arafat AM, Pfeiffer AF, Lieske S, Oyadomari S, Ron D, Samuel VT, Shulman GI. Birkenfeld AL, et al. Among authors: lieske s. J Biol Chem. 2011 Oct 21;286(42):36163-70. doi: 10.1074/jbc.M111.228817. Epub 2011 Aug 5. J Biol Chem. 2011. PMID: 21832042 Free PMC article.
The mammalian INDY homolog is induced by CREB in a rat model of type 2 diabetes.
Neuschäfer-Rube F, Lieske S, Kuna M, Henkel J, Perry RJ, Erion DM, Pesta D, Willmes DM, Brachs S, von Loeffelholz C, Tolkachov A, Schupp M, Pathe-Neuschäfer-Rube A, Pfeiffer AF, Shulman GI, Püschel GP, Birkenfeld AL. Neuschäfer-Rube F, et al. Among authors: lieske s. Diabetes. 2014 Mar;63(3):1048-57. doi: 10.2337/db13-0749. Epub 2013 Nov 12. Diabetes. 2014. PMID: 24222346 Free PMC article.
The longevity gene mIndy (I'm Not Dead, Yet) affects blood pressure through sympathoadrenal mechanisms.
Willmes DM, Daniels M, Kurzbach A, Lieske S, Bechmann N, Schumann T, Henke C, El-Agroudy NN, Da Costa Goncalves AC, Peitzsch M, Hofmann A, Kanczkowski W, Kräker K, Müller DN, Morawietz H, Deussen A, Wagner M, El-Armouche A, Helfand SL, Bornstein SR, de Cabo R, Bernier M, Eisenhofer G, Tank J, Jordan J, Birkenfeld AL. Willmes DM, et al. Among authors: lieske s. JCI Insight. 2021 Jan 25;6(2):e136083. doi: 10.1172/jci.insight.136083. JCI Insight. 2021. PMID: 33491666 Free PMC article.
Glucagon Decreases IGF-1 Bioactivity in Humans, Independently of Insulin, by Modulating Its Binding Proteins.
Sarem Z, Bumke-Vogt C, Mahmoud AM, Assefa B, Weickert MO, Adamidou A, Bähr V, Frystyk J, Möhlig M, Spranger J, Lieske S, Birkenfeld AL, Pfeiffer AFH, Arafat AM. Sarem Z, et al. Among authors: lieske s. J Clin Endocrinol Metab. 2017 Sep 1;102(9):3480-3490. doi: 10.1210/jc.2017-00558. J Clin Endocrinol Metab. 2017. PMID: 28911141 Free PMC article. Clinical Trial.
Natriuretic peptides enhance the oxidative capacity of human skeletal muscle.
Engeli S, Birkenfeld AL, Badin PM, Bourlier V, Louche K, Viguerie N, Thalamas C, Montastier E, Larrouy D, Harant I, de Glisezinski I, Lieske S, Reinke J, Beckmann B, Langin D, Jordan J, Moro C. Engeli S, et al. Among authors: lieske s. J Clin Invest. 2012 Dec;122(12):4675-9. doi: 10.1172/JCI64526. Epub 2012 Nov 1. J Clin Invest. 2012. PMID: 23114600 Free PMC article.
Increased lipogenesis in spite of upregulated hepatic 5'AMP-activated protein kinase in human non-alcoholic fatty liver.
von Loeffelholz C, Döcke S, Lock JF, Lieske S, Horn P, Kriebel J, Wahl S, Singmann P, de Las Heras Gala T, Grallert H, Raschzok N, Sauer IM, Heller R, Jahreis G, Claus RA, Bauer M, Stockmann M, Birkenfeld AL, Pfeiffer AFH. von Loeffelholz C, et al. Among authors: lieske s. Hepatol Res. 2017 Aug;47(9):890-901. doi: 10.1111/hepr.12825. Epub 2016 Nov 18. Hepatol Res. 2017. PMID: 27689765
36 results