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Downregulation of homologous recombination DNA repair genes by HDAC inhibition in prostate cancer is mediated through the E2F1 transcription factor.
Kachhap SK, Rosmus N, Collis SJ, Kortenhorst MS, Wissing MD, Hedayati M, Shabbeer S, Mendonca J, Deangelis J, Marchionni L, Lin J, Höti N, Nortier JW, DeWeese TL, Hammers H, Carducci MA. Kachhap SK, et al. Among authors: lin j. PLoS One. 2010 Jun 18;5(6):e11208. doi: 10.1371/journal.pone.0011208. PLoS One. 2010. PMID: 20585447 Free PMC article.
Pharmacodynamic study of disulfiram in men with non-metastatic recurrent prostate cancer.
Schweizer MT, Lin J, Blackford A, Bardia A, King S, Armstrong AJ, Rudek MA, Yegnasubramanian S, Carducci MA. Schweizer MT, et al. Among authors: lin j. Prostate Cancer Prostatic Dis. 2013 Dec;16(4):357-61. doi: 10.1038/pcan.2013.28. Epub 2013 Aug 20. Prostate Cancer Prostatic Dis. 2013. PMID: 23958896 Free PMC article. Clinical Trial.
A non-comparative randomized phase II study of 2 doses of ATN-224, a copper/zinc superoxide dismutase inhibitor, in patients with biochemically recurrent hormone-naïve prostate cancer.
Lin J, Zahurak M, Beer TM, Ryan CJ, Wilding G, Mathew P, Morris M, Callahan JA, Gordon G, Reich SD, Carducci MA, Antonarakis ES. Lin J, et al. Urol Oncol. 2013 Jul;31(5):581-8. doi: 10.1016/j.urolonc.2011.04.009. Epub 2011 Aug 4. Urol Oncol. 2013. PMID: 21816640 Free PMC article. Clinical Trial.
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