Lin MH - Search Results

1

Relationship between passive permeability, efflux, and predictability of clearance from in vitro metabolic intrinsic clearance.

Huang L, Berry L, Ganga S, Janosky B, Chen A, Roberts J, Colletti AE, Lin MH. Huang L, et al. Among authors: lin mh. Drug Metab Dispos. 2010 Feb;38(2):223-31. doi: 10.1124/dmd.109.029066. Epub 2009 Oct 29. Drug Metab Dispos. 2010. PMID: 19875499

2

Prediction of V(ss) from in vitro tissue-binding studies.

Berry LM, Roberts J, Be X, Zhao Z, Lin MH. Berry LM, et al. Among authors: lin mh. Drug Metab Dispos. 2010 Jan;38(1):115-21. doi: 10.1124/dmd.109.029629. Drug Metab Dispos. 2010. PMID: 19797608

3

Use of uptake intrinsic clearance from attached rat hepatocytes to predict hepatic clearance for poorly permeable compounds.

Huang L, Chen A, Roberts J, Janosky B, Be X, Berry L, Lin MH. Huang L, et al. Among authors: lin mh. Xenobiotica. 2012 Sep;42(9):830-40. doi: 10.3109/00498254.2012.667847. Epub 2012 Mar 22. Xenobiotica. 2012. PMID: 22439758

4

Differential role of P-glycoprotein and breast cancer resistance protein in drug distribution into brain, CSF and peripheral nerve tissues in rats.

Huang L, Li X, Roberts J, Janosky B, Lin MH. Huang L, et al. Among authors: lin mh. Xenobiotica. 2015;45(6):547-55. doi: 10.3109/00498254.2014.997324. Epub 2014 Dec 24. Xenobiotica. 2015. PMID: 25539457

5

Bioactivation of isothiazoles: minimizing the risk of potential toxicity in drug discovery.

Teffera Y, Choquette D, Liu J, Colletti AE, Hollis LS, Lin MH, Zhao Z. Teffera Y, et al. Among authors: lin mh. Chem Res Toxicol. 2010 Nov 15;23(11):1743-52. doi: 10.1021/tx100208k. Epub 2010 Sep 8. Chem Res Toxicol. 2010. PMID: 20825217

6

In vitro and in vivo pharmacokinetic characterizations of AMG 900, an orally bioavailable small molecule inhibitor of aurora kinases.

Huang L, Be X, Berry L, Moore E, Janosky B, Wells M, Pan WJ, Zhao Z, Lin MH. Huang L, et al. Among authors: lin mh. Xenobiotica. 2011 May;41(5):400-8. doi: 10.3109/00498254.2010.548534. Epub 2011 Feb 4. Xenobiotica. 2011. PMID: 21294625

7

Dynamic modeling of cytochrome P450 inhibition in vitro: impact of inhibitor depletion on IC₅₀ shift.

Berry LM, Zhao Z, Lin MH. Berry LM, et al. Among authors: lin mh. Drug Metab Dispos. 2013 Jul;41(7):1433-41. doi: 10.1124/dmd.113.051508. Epub 2013 May 6. Drug Metab Dispos. 2013. PMID: 23649703

8

Gender effects on rat metabolism of AMG 900, an orally available small molecule aurora kinase inhibitor.

Waldon D, Berry L, Lin MH, Schenkel L, Hollis LS, Zhao Z. Waldon D, et al. Among authors: lin mh. Drug Metab Lett. 2011 Dec;5(4):290-7. doi: 10.2174/187231211798472557. Drug Metab Lett. 2011. PMID: 22022868

9

Discovery and optimization of a potent and selective triazolopyridinone series of c-Met inhibitors.

Bode CM, Boezio AA, Albrecht BK, Bellon SF, Berry L, Broome MA, Choquette D, Dussault I, Lewis RT, Lin MH, Rex K, Whittington DA, Yang Y, Harmange JC. Bode CM, et al. Among authors: lin mh. Bioorg Med Chem Lett. 2012 Jun 15;22(12):4089-93. doi: 10.1016/j.bmcl.2012.04.072. Epub 2012 Apr 25. Bioorg Med Chem Lett. 2012. PMID: 22595176

10

Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors.

Boezio AA, Berry L, Albrecht BK, Bauer D, Bellon SF, Bode C, Chen A, Choquette D, Dussault I, Fang M, Hirai S, Kaplan-Lefko P, Larrow JF, Lin MH, Lohman J, Potashman MH, Qu Y, Rex K, Santostefano M, Shah K, Shimanovich R, Springer SK, Teffera Y, Yang Y, Zhang Y, Harmange JC. Boezio AA, et al. Among authors: lin mh. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6307-12. doi: 10.1016/j.bmcl.2009.09.096. Epub 2009 Sep 27. Bioorg Med Chem Lett. 2009. PMID: 19819693

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