Lin X - Search Results

1

Design, synthesis and identification of N, N-dibenzylcinnamamide (DBC) derivatives as novel ligands for α-synuclein fibrils by SPR evaluation system.

Chen YF, Bian J, Zhang P, Bu LL, Shen Y, Yu WB, Lu XH, Lin X, Ye DY, Wang J, Chu Y. Chen YF, et al. Among authors: lin x. Bioorg Med Chem. 2020 Apr 1;28(7):115358. doi: 10.1016/j.bmc.2020.115358. Epub 2020 Feb 6. Bioorg Med Chem. 2020. PMID: 32081628

2

Discovery of styrylaniline derivatives as novel alpha-synuclein aggregates ligands.

Bian J, Liu YQ, He J, Lin X, Qiu CY, Yu WB, Shen Y, Zhu ZY, Ye DY, Wang J, Chu Y. Bian J, et al. Among authors: lin x. Eur J Med Chem. 2021 Dec 15;226:113887. doi: 10.1016/j.ejmech.2021.113887. Epub 2021 Oct 2. Eur J Med Chem. 2021. PMID: 34624824

3

Discovery of Novel Benzothiazepinones as Irreversible Covalent Glycogen Synthase Kinase 3β Inhibitors for the Treatment of Acute Promyelocytic Leukemia.

Zhang P, Min Z, Gao Y, Bian J, Lin X, He J, Ye D, Li Y, Peng C, Cheng Y, Chu Y. Zhang P, et al. Among authors: lin x. J Med Chem. 2021 Jun 10;64(11):7341-7358. doi: 10.1021/acs.jmedchem.0c02254. Epub 2021 May 24. J Med Chem. 2021. PMID: 34027661

4

Discovery of novel 2H-chromene-3-carbonyl derivatives as selective estrogen receptor degraders (SERDs): Design, synthesis and biological evaluation.

Lu X, Teng Y, Lin X, Xiao M, Liu C, Chi X, Zhang Y, Luo G, Xiang H. Lu X, et al. Among authors: lin x. Bioorg Chem. 2021 Apr;109:104714. doi: 10.1016/j.bioorg.2021.104714. Epub 2021 Feb 9. Bioorg Chem. 2021. PMID: 33618254

5

Discovery of novel steroidal-chalcone hybrids with potent and selective activity against triple-negative breast cancer.

Hou Q, Lin X, Lu X, Bai C, Wei H, Luo G, Xiang H. Hou Q, et al. Among authors: lin x. Bioorg Med Chem. 2020 Dec 1;28(23):115763. doi: 10.1016/j.bmc.2020.115763. Epub 2020 Sep 12. Bioorg Med Chem. 2020. PMID: 32992255

6

Targeting species specific amino acid residues: Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors and potential anti-opportunistic infection agents.

Shah K, Lin X, Queener SF, Cody V, Pace J, Gangjee A. Shah K, et al. Among authors: lin x. Bioorg Med Chem. 2018 May 15;26(9):2640-2650. doi: 10.1016/j.bmc.2018.04.032. Epub 2018 Apr 17. Bioorg Med Chem. 2018. PMID: 29691153 Free PMC article.

7

Synthesis and biological evaluation of 3-aryl-quinolin derivatives as anti-breast cancer agents targeting ERα and VEGFR-2.

Li X, Wu C, Lin X, Cai X, Liu L, Luo G, You Q, Xiang H. Li X, et al. Among authors: lin x. Eur J Med Chem. 2019 Jan 1;161:445-455. doi: 10.1016/j.ejmech.2018.10.045. Epub 2018 Oct 19. Eur J Med Chem. 2019. PMID: 30384047

8

Design, synthesis, and biological evaluation of 2,4-diamino-5-methyl-6-substituted-pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors.

Gangjee A, Lin X, Queener SF. Gangjee A, et al. Among authors: lin x. J Med Chem. 2004 Jul 1;47(14):3689-92. doi: 10.1021/jm0306327. J Med Chem. 2004. PMID: 15214795

9

Progress in PD-1/PD-L1 pathway inhibitors: From biomacromolecules to small molecules.

Lin X, Lu X, Luo G, Xiang H. Lin X, et al. Eur J Med Chem. 2020 Jan 15;186:111876. doi: 10.1016/j.ejmech.2019.111876. Epub 2019 Nov 15. Eur J Med Chem. 2020. PMID: 31761384 Review.

10

Development of novel tetrahydroisoquinoline-hydroxamate conjugates as potent dual SERDs/HDAC inhibitors for the treatment of breast cancer.

Luo G, Lin X, Ren S, Wu S, Wang X, Ma L, Xiang H. Luo G, et al. Among authors: lin x. Eur J Med Chem. 2021 Dec 15;226:113870. doi: 10.1016/j.ejmech.2021.113870. Epub 2021 Sep 25. Eur J Med Chem. 2021. PMID: 34610548

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