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Page 1
Sensing and Signaling of Methionine Metabolism.
Lauinger L, Kaiser P. Lauinger L, et al. Metabolites. 2021 Jan 31;11(2):83. doi: 10.3390/metabo11020083. Metabolites. 2021. PMID: 33572567 Free PMC article. Review.
Cdc48 cofactor Shp1 regulates signal-induced SCFMet30 disassembly.
Lauinger L, Flick K, Yen JL, Mathur R, Kaiser P. Lauinger L, et al. Proc Natl Acad Sci U S A. 2020 Sep 1;117(35):21319-21327. doi: 10.1073/pnas.1922891117. Epub 2020 Aug 18. Proc Natl Acad Sci U S A. 2020. PMID: 32817489 Free PMC article.
Discovery of compounds that reactivate p53 mutants in vitro and in vivo.
Durairaj G, Demir Ö, Lim B, Baronio R, Tifrea D, Hall LV, DeForest JC, Lauinger L, Jebril Fallatah MM, Yu C, Bae H, Lin DW, Kim JK, Salehi F, Jang C, Qiao F, Lathrop RH, Huang L, Edwards R, Rychnovsky S, Amaro RE, Kaiser P. Durairaj G, et al. Among authors: lauinger l. Cell Chem Biol. 2022 Sep 15;29(9):1381-1395.e13. doi: 10.1016/j.chembiol.2022.07.003. Epub 2022 Aug 10. Cell Chem Biol. 2022. PMID: 35948006 Free PMC article.
Proteomics Links Ubiquitin Chain Topology Change to Transcription Factor Activation.
Li Y, Dammer EB, Gao Y, Lan Q, Villamil MA, Duong DM, Zhang C, Ping L, Lauinger L, Flick K, Xu Z, Wei W, Xing X, Chang L, Jin J, Hong X, Zhu Y, Wu J, Deng Z, He F, Kaiser P, Xu P. Li Y, et al. Among authors: lauinger l. Mol Cell. 2019 Oct 3;76(1):126-137.e7. doi: 10.1016/j.molcel.2019.07.001. Epub 2019 Aug 20. Mol Cell. 2019. PMID: 31444107 Free PMC article.
Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases.
Lauinger L, Li J, Shostak A, Cemel IA, Ha N, Zhang Y, Merkl PE, Obermeyer S, Stankovic-Valentin N, Schafmeier T, Wever WJ, Bowers AA, Carter KP, Palmer AE, Tschochner H, Melchior F, Deshaies RJ, Brunner M, Diernfellner A. Lauinger L, et al. Nat Chem Biol. 2017 Jul;13(7):709-714. doi: 10.1038/nchembio.2370. Epub 2017 May 1. Nat Chem Biol. 2017. PMID: 28459440 Free PMC article.