Lindorff-Larsen K - Search Results

1

Conserved conformational dynamics determine enzyme activity.

Torgeson KR, Clarkson MW, Granata D, Lindorff-Larsen K, Page R, Peti W. Torgeson KR, et al. Sci Adv. 2022 Aug 5;8(31):eabo5546. doi: 10.1126/sciadv.abo5546. Epub 2022 Aug 3. Sci Adv. 2022. PMID: 35921420 Free PMC article.

2

Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery.

Choy MS, Li Y, Machado LESF, Kunze MBA, Connors CR, Wei X, Lindorff-Larsen K, Page R, Peti W. Choy MS, et al. Mol Cell. 2017 Feb 16;65(4):644-658.e5. doi: 10.1016/j.molcel.2017.01.014. Mol Cell. 2017. PMID: 28212750 Free PMC article.

3

Dynamic activation and regulation of the mitogen-activated protein kinase p38.

Kumar GS, Clarkson MW, Kunze MBA, Granata D, Wand AJ, Lindorff-Larsen K, Page R, Peti W. Kumar GS, et al. Proc Natl Acad Sci U S A. 2018 May 1;115(18):4655-4660. doi: 10.1073/pnas.1721441115. Epub 2018 Apr 16. Proc Natl Acad Sci U S A. 2018. PMID: 29666261 Free PMC article.

4

Conformational ensembles of RNA oligonucleotides from integrating NMR and molecular simulations.

Bottaro S, Bussi G, Kennedy SD, Turner DH, Lindorff-Larsen K. Bottaro S, et al. Sci Adv. 2018 May 18;4(5):eaar8521. doi: 10.1126/sciadv.aar8521. eCollection 2018 May. Sci Adv. 2018. PMID: 29795785 Free PMC article.

5

Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments.

Bouchard JJ, Otero JH, Scott DC, Szulc E, Martin EW, Sabri N, Granata D, Marzahn MR, Lindorff-Larsen K, Salvatella X, Schulman BA, Mittag T. Bouchard JJ, et al. Mol Cell. 2018 Oct 4;72(1):19-36.e8. doi: 10.1016/j.molcel.2018.08.027. Epub 2018 Sep 20. Mol Cell. 2018. PMID: 30244836 Free PMC article.

6

Order and disorder-An integrative structure of the full-length human growth hormone receptor.

Kassem N, Araya-Secchi R, Bugge K, Barclay A, Steinocher H, Khondker A, Wang Y, Lenard AJ, Bürck J, Sahin C, Ulrich AS, Landreh M, Pedersen MC, Rheinstädter MC, Pedersen PA, Lindorff-Larsen K, Arleth L, Kragelund BB. Kassem N, et al. Sci Adv. 2021 Jun 30;7(27):eabh3805. doi: 10.1126/sciadv.abh3805. Print 2021 Jun. Sci Adv. 2021. PMID: 34193419 Free PMC article.

7

Synergistic stabilization of a double mutant in chymotrypsin inhibitor 2 from a library screen in E. coli.

Hamborg L, Granata D, Olsen JG, Roche JV, Pedersen LE, Nielsen AT, Lindorff-Larsen K, Teilum K. Hamborg L, et al. Commun Biol. 2021 Aug 18;4(1):980. doi: 10.1038/s42003-021-02490-7. Commun Biol. 2021. PMID: 34408246 Free PMC article.

8

The Role of Protein Loops and Linkers in Conformational Dynamics and Allostery.

Papaleo E, Saladino G, Lambrughi M, Lindorff-Larsen K, Gervasio FL, Nussinov R. Papaleo E, et al. Chem Rev. 2016 Jun 8;116(11):6391-423. doi: 10.1021/acs.chemrev.5b00623. Epub 2016 Feb 18. Chem Rev. 2016. PMID: 26889708 Review.

9

Role of protein dynamics in transmembrane receptor signalling.

Wang Y, Bugge K, Kragelund BB, Lindorff-Larsen K. Wang Y, et al. Curr Opin Struct Biol. 2018 Feb;48:74-82. doi: 10.1016/j.sbi.2017.10.017. Epub 2017 Nov 11. Curr Opin Struct Biol. 2018. PMID: 29136528 Review.

10

Substrate-induced conformational dynamics of the dopamine transporter.

Nielsen AK, Möller IR, Wang Y, Rasmussen SGF, Lindorff-Larsen K, Rand KD, Loland CJ. Nielsen AK, et al. Nat Commun. 2019 Jun 20;10(1):2714. doi: 10.1038/s41467-019-10449-w. Nat Commun. 2019. PMID: 31221956 Free PMC article.

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