Ling NXY - Search Results

1

Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator.

Ovens AJ, Gee YS, Ling NXY, Yu D, Hardee JP, Chung JD, Ngoei KRW, Waters NJ, Hoffman NJ, Scott JW, Loh K, Spengler K, Heller R, Parker MW, Lynch GS, Huang F, Galic S, Kemp BE, Baell JB, Oakhill JS, Langendorf CG. Ovens AJ, et al. Among authors: ling nxy. Biochem J. 2022 Jun 17;479(11):1181-1204. doi: 10.1042/BCJ20220067. Biochem J. 2022. PMID: 35552369 Free PMC article.

2

β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK).

Oakhill JS, Chen ZP, Scott JW, Steel R, Castelli LA, Ling N, Macaulay SL, Kemp BE. Oakhill JS, et al. Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19237-41. doi: 10.1073/pnas.1009705107. Epub 2010 Oct 25. Proc Natl Acad Sci U S A. 2010. PMID: 20974912 Free PMC article.

3

AMPK is a direct adenylate charge-regulated protein kinase.

Oakhill JS, Steel R, Chen ZP, Scott JW, Ling N, Tam S, Kemp BE. Oakhill JS, et al. Science. 2011 Jun 17;332(6036):1433-5. doi: 10.1126/science.1200094. Science. 2011. PMID: 21680840

4

ATP sensitive bi-quinoline activator of the AMP-activated protein kinase.

Scott JW, Oakhill JS, Ling NX, Langendorf CG, Foitzik RC, Kemp BE, Issinger OG. Scott JW, et al. Biochem Biophys Res Commun. 2014 Jan 10;443(2):435-40. doi: 10.1016/j.bbrc.2013.11.130. Epub 2013 Dec 8. Biochem Biophys Res Commun. 2014. PMID: 24332941

5

Small molecule drug A-769662 and AMP synergistically activate naive AMPK independent of upstream kinase signaling.

Scott JW, Ling N, Issa SM, Dite TA, O'Brien MT, Chen ZP, Galic S, Langendorf CG, Steinberg GR, Kemp BE, Oakhill JS. Scott JW, et al. Chem Biol. 2014 May 22;21(5):619-27. doi: 10.1016/j.chembiol.2014.03.006. Epub 2014 Apr 17. Chem Biol. 2014. PMID: 24746562

6

Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release.

Scott JW, Galic S, Graham KL, Foitzik R, Ling NX, Dite TA, Issa SM, Langendorf CG, Weng QP, Thomas HE, Kay TW, Birnberg NC, Steinberg GR, Kemp BE, Oakhill JS. Scott JW, et al. Chem Biol. 2015 Jun 18;22(6):705-11. doi: 10.1016/j.chembiol.2015.05.011. Chem Biol. 2015. PMID: 26091167

7

Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding.

Langendorf CG, Ngoei KRW, Scott JW, Ling NXY, Issa SMA, Gorman MA, Parker MW, Sakamoto K, Oakhill JS, Kemp BE. Langendorf CG, et al. Among authors: ling nxy. Nat Commun. 2016 Mar 8;7:10912. doi: 10.1038/ncomms10912. Nat Commun. 2016. PMID: 26952388 Free PMC article.

8

β-subunit myristoylation functions as an energy sensor by modulating the dynamics of AMP-activated Protein Kinase.

Ali N, Ling N, Krishnamurthy S, Oakhill JS, Scott JW, Stapleton DI, Kemp BE, Anand GS, Gooley PR. Ali N, et al. Sci Rep. 2016 Dec 21;6:39417. doi: 10.1038/srep39417. Sci Rep. 2016. PMID: 28000716 Free PMC article.

9

Impact of Genetic Variation on Human CaMKK2 Regulation by Ca²⁺-Calmodulin and Multisite Phosphorylation.

O'Brien MT, Oakhill JS, Ling NX, Langendorf CG, Hoque A, Dite TA, Means AR, Kemp BE, Scott JW. O'Brien MT, et al. Sci Rep. 2017 Feb 23;7:43264. doi: 10.1038/srep43264. Sci Rep. 2017. PMID: 28230171 Free PMC article.

10

The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs.

Dite TA, Ling NXY, Scott JW, Hoque A, Galic S, Parker BL, Ngoei KRW, Langendorf CG, O'Brien MT, Kundu M, Viollet B, Steinberg GR, Sakamoto K, Kemp BE, Oakhill JS. Dite TA, et al. Among authors: ling nxy. Nat Commun. 2017 Sep 18;8(1):571. doi: 10.1038/s41467-017-00628-y. Nat Commun. 2017. PMID: 28924239 Free PMC article.

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