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Engineered EVs designed to target diseases of the CNS.
Nieland L, Mahjoum S, Grandell E, Breyne K, Breakefield XO. Nieland L, et al. J Control Release. 2023 Apr;356:493-506. doi: 10.1016/j.jconrel.2023.03.009. Epub 2023 Mar 15. J Control Release. 2023. PMID: 36907561 Free PMC article. Review.
CRISPR-Cas knockout of miR21 reduces glioma growth.
Nieland L, van Solinge TS, Cheah PS, Morsett LM, El Khoury J, Rissman JI, Kleinstiver BP, Broekman MLD, Breakefield XO, Abels ER. Nieland L, et al. Mol Ther Oncolytics. 2022 Apr 6;25:121-136. doi: 10.1016/j.omto.2022.04.001. eCollection 2022 Jun 16. Mol Ther Oncolytics. 2022. PMID: 35572197 Free PMC article.
Roles of extracellular vesicles in glioblastoma: foes, friends and informers.
Lunavat TR, Nieland L, Vrijmoet AB, Zargani-Piccardi A, Samaha Y, Breyne K, Breakefield XO. Lunavat TR, et al. Among authors: nieland l. Front Oncol. 2023 Nov 24;13:1291177. doi: 10.3389/fonc.2023.1291177. eCollection 2023. Front Oncol. 2023. PMID: 38074665 Free PMC article. Review.