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DJ-1 is an essential downstream mediator in PINK1/parkin-dependent mitophagy.
Imberechts D, Kinnart I, Wauters F, Terbeek J, Manders L, Wierda K, Eggermont K, Madeiro RF, Sue C, Verfaillie C, Vandenberghe W. Imberechts D, et al. Among authors: manders l. Brain. 2022 Dec 19;145(12):4368-4384. doi: 10.1093/brain/awac313. Brain. 2022. PMID: 36039535 Free PMC article.
Elevated α-synuclein levels inhibit mitophagic flux.
Kinnart I, Manders L, Heyninck T, Imberechts D, Praschberger R, Schoovaerts N, Verfaillie C, Verstreken P, Vandenberghe W. Kinnart I, et al. Among authors: manders l. NPJ Parkinsons Dis. 2024 Apr 9;10(1):80. doi: 10.1038/s41531-024-00696-0. NPJ Parkinsons Dis. 2024. PMID: 38594264 Free PMC article.