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The BCL2 antagonist ABT-199 triggers apoptosis, and augments ibrutinib and idelalisib mediated cytotoxicity in CXCR4 Wild-type and CXCR4 WHIM mutated Waldenstrom macroglobulinaemia cells.
Cao Y, Yang G, Hunter ZR, Liu X, Xu L, Chen J, Tsakmaklis N, Hatjiharissi E, Kanan S, Davids MS, Castillo JJ, Treon SP. Cao Y, et al. Among authors: liu x. Br J Haematol. 2015 Jul;170(1):134-8. doi: 10.1111/bjh.13278. Epub 2015 Jan 12. Br J Haematol. 2015. PMID: 25582069 Free article. No abstract available.
Soluble CD27 is a faithful marker of disease burden and is unaffected by the rituximab-induced IgM flare, as well as by plasmapheresis, in patients with Waldenström's macroglobulinemia.
Ciccarelli BT, Yang G, Hatjiharissi E, Ioakimidis L, Patterson CJ, Manning RJ, Xu L, Liu X, Tseng H, Gong P, Sun J, Zhou Y, Treon SP. Ciccarelli BT, et al. Among authors: liu x. Clin Lymphoma Myeloma. 2009 Mar;9(1):56-8. doi: 10.3816/CLM.2009.n.014. Clin Lymphoma Myeloma. 2009. PMID: 19362974
IgA and IgG hypogammaglobulinemia in Waldenström's macroglobulinemia.
Hunter ZR, Manning RJ, Hanzis C, Ciccarelli BT, Ioakimidis L, Patterson CJ, Lewicki MC, Tseng H, Gong P, Liu X, Zhou Y, Yang G, Sun J, Xu L, Sheehy P, Morra M, Treon SP. Hunter ZR, et al. Among authors: liu x. Haematologica. 2010 Mar;95(3):470-5. doi: 10.3324/haematol.2009.010348. Epub 2009 Nov 10. Haematologica. 2010. PMID: 19903677 Free PMC article.
Histone deacetylase inhibitors demonstrate significant preclinical activity as single agents, and in combination with bortezomib in Waldenström's macroglobulinemia.
Sun JY, Xu L, Tseng H, Ciccarelli B, Fulciniti M, Hunter ZR, Maghsoudi K, Hatjiharissi E, Zhou Y, Yang G, Zhu B, Liu X, Gong P, Ioakimidis L, Sheehy P, Patterson CJ, Munshi NC, O'Connor OA, Treon SP. Sun JY, et al. Among authors: liu x. Clin Lymphoma Myeloma Leuk. 2011 Feb;11(1):152-6. doi: 10.3816/CLML.2011.n.036. Clin Lymphoma Myeloma Leuk. 2011. PMID: 21454220
Vorinostat induced cellular stress disrupts the p38 mitogen activated protein kinase and extracellular signal regulated kinase pathways leading to apoptosis in Waldenström macroglobulinemia cells.
Sun JY, Tseng H, Xu L, Hunter Z, Ciccarelli B, Fulciniti M, Zhu B, Maghsoudi K, Yang G, Gong P, Zhou Y, Liu X, Munshi NC, Patterson CJ, Treon SP. Sun JY, et al. Among authors: liu x. Leuk Lymphoma. 2011 Sep;52(9):1777-86. doi: 10.3109/10428194.2011.577850. Epub 2011 Jun 10. Leuk Lymphoma. 2011. PMID: 21657958
MYD88 L265P somatic mutation in Waldenström's macroglobulinemia.
Treon SP, Xu L, Yang G, Zhou Y, Liu X, Cao Y, Sheehy P, Manning RJ, Patterson CJ, Tripsas C, Arcaini L, Pinkus GS, Rodig SJ, Sohani AR, Harris NL, Laramie JM, Skifter DA, Lincoln SE, Hunter ZR. Treon SP, et al. Among authors: liu x. N Engl J Med. 2012 Aug 30;367(9):826-33. doi: 10.1056/NEJMoa1200710. N Engl J Med. 2012. PMID: 22931316 Free article.
MYD88 L265P in Waldenström macroglobulinemia, immunoglobulin M monoclonal gammopathy, and other B-cell lymphoproliferative disorders using conventional and quantitative allele-specific polymerase chain reaction.
Xu L, Hunter ZR, Yang G, Zhou Y, Cao Y, Liu X, Morra E, Trojani A, Greco A, Arcaini L, Varettoni M, Brown JR, Tai YT, Anderson KC, Munshi NC, Patterson CJ, Manning RJ, Tripsas CK, Lindeman NI, Treon SP. Xu L, et al. Among authors: liu x. Blood. 2013 Mar 14;121(11):2051-8. doi: 10.1182/blood-2012-09-454355. Epub 2013 Jan 15. Blood. 2013. PMID: 23321251 Free PMC article.
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