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Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome.
Shen C, Li R, Negro R, Cheng J, Vora SM, Fu TM, Wang A, He K, Andreeva L, Gao P, Tian Z, Flavell RA, Zhu S, Wu H. Shen C, et al. Among authors: andreeva l. Cell. 2021 Nov 11;184(23):5759-5774.e20. doi: 10.1016/j.cell.2021.09.032. Epub 2021 Oct 21. Cell. 2021. PMID: 34678144 Free PMC article.
Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome.
Sharif H, Wang L, Wang WL, Magupalli VG, Andreeva L, Qiao Q, Hauenstein AV, Wu Z, Núñez G, Mao Y, Wu H. Sharif H, et al. Among authors: andreeva l. Nature. 2019 Jun;570(7761):338-343. doi: 10.1038/s41586-019-1295-z. Epub 2019 Jun 12. Nature. 2019. PMID: 31189953 Free PMC article.
STING condensates on ER limit IFN response.
Andreeva L, Wu H. Andreeva L, et al. Nat Cell Biol. 2021 Apr;23(4):299-300. doi: 10.1038/s41556-021-00662-5. Nat Cell Biol. 2021. PMID: 33833430 Free PMC article.
BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity.
Bittner ZA, Liu X, Mateo Tortola M, Tapia-Abellán A, Shankar S, Andreeva L, Mangan M, Spalinger M, Kalbacher H, Düwell P, Lovotti M, Bosch K, Dickhöfer S, Marcu A, Stevanović S, Herster F, Cardona Gloria Y, Chang TH, Bork F, Greve CL, Löffler MW, Wolz OO, Schilling NA, Kümmerle-Deschner JB, Wagner S, Delor A, Grimbacher B, Hantschel O, Scharl M, Wu H, Latz E, Weber ANR. Bittner ZA, et al. Among authors: andreeva l. J Exp Med. 2021 Nov 1;218(11):e20201656. doi: 10.1084/jem.20201656. Epub 2021 Sep 23. J Exp Med. 2021. PMID: 34554188 Free PMC article.
Cytosolic RNA:DNA hybrids activate the cGAS-STING axis.
Mankan AK, Schmidt T, Chauhan D, Goldeck M, Höning K, Gaidt M, Kubarenko AV, Andreeva L, Hopfner KP, Hornung V. Mankan AK, et al. Among authors: andreeva l. EMBO J. 2014 Dec 17;33(24):2937-46. doi: 10.15252/embj.201488726. Epub 2014 Nov 25. EMBO J. 2014. PMID: 25425575 Free PMC article.
Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA.
Herzner AM, Hagmann CA, Goldeck M, Wolter S, Kübler K, Wittmann S, Gramberg T, Andreeva L, Hopfner KP, Mertens C, Zillinger T, Jin T, Xiao TS, Bartok E, Coch C, Ackermann D, Hornung V, Ludwig J, Barchet W, Hartmann G, Schlee M. Herzner AM, et al. Among authors: andreeva l. Nat Immunol. 2015 Oct;16(10):1025-33. doi: 10.1038/ni.3267. Epub 2015 Sep 7. Nat Immunol. 2015. PMID: 26343537 Free PMC article.