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Loss of TET2 in human hematopoietic stem cells alters the development and function of neutrophils.
Huerga Encabo H, Aramburu IV, Garcia-Albornoz M, Piganeau M, Wood H, Song A, Ferrelli A, Sharma A, Minutti CM, Domart MC, Papazoglou D, Gurashi K, Llorian Sopena M, Goldstone R, Fallesen T, Wang Q, Ariza-McNaughton L, Wiseman DH, Batta K, Gupta R, Papayannopoulos V, Bonnet D. Huerga Encabo H, et al. Among authors: llorian sopena m. Cell Stem Cell. 2023 Jun 1;30(6):781-799.e9. doi: 10.1016/j.stem.2023.05.004. Cell Stem Cell. 2023. PMID: 37267914 Free article.
Pioneer factor ASCL1 cooperates with the mSWI/SNF complex at distal regulatory elements to regulate human neural differentiation.
Păun O, Tan YX, Patel H, Strohbuecker S, Ghanate A, Cobolli-Gigli C, Llorian Sopena M, Gerontogianni L, Goldstone R, Ang SL, Guillemot F, Dias C. Păun O, et al. Among authors: llorian sopena m. Genes Dev. 2023 Mar 1;37(5-6):218-242. doi: 10.1101/gad.350269.122. Epub 2023 Mar 17. Genes Dev. 2023. PMID: 36931659 Free PMC article.
Therapeutic KRASG12C inhibition drives effective interferon-mediated antitumor immunity in immunogenic lung cancers.
Mugarza E, van Maldegem F, Boumelha J, Moore C, Rana S, Llorian Sopena M, East P, Ambler R, Anastasiou P, Romero-Clavijo P, Valand K, Cole M, Molina-Arcas M, Downward J. Mugarza E, et al. Among authors: llorian sopena m. Sci Adv. 2022 Jul 22;8(29):eabm8780. doi: 10.1126/sciadv.abm8780. Epub 2022 Jul 20. Sci Adv. 2022. PMID: 35857848 Free PMC article.
USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer.
Nelson JK, Thin MZ, Evan T, Howell S, Wu M, Almeida B, Legrave N, Koenis DS, Koifman G, Sugimoto Y, Llorian Sopena M, MacRae J, Nye E, Howell M, Snijders AP, Prachalias A, Zen Y, Sarker D, Behrens A. Nelson JK, et al. Among authors: llorian sopena m. Nat Commun. 2022 Apr 19;13(1):2070. doi: 10.1038/s41467-022-29684-9. Nat Commun. 2022. PMID: 35440539 Free PMC article.
Permissive selection followed by affinity-based proliferation of GC light zone B cells dictates cell fate and ensures clonal breadth.
Nakagawa R, Toboso-Navasa A, Schips M, Young G, Bhaw-Rosun L, Llorian-Sopena M, Chakravarty P, Sesay AK, Kassiotis G, Meyer-Hermann M, Calado DP. Nakagawa R, et al. Among authors: llorian sopena m. Proc Natl Acad Sci U S A. 2021 Jan 12;118(2):e2016425118. doi: 10.1073/pnas.2016425118. Proc Natl Acad Sci U S A. 2021. PMID: 33419925 Free PMC article.
Critical role of WNK1 in MYC-dependent early mouse thymocyte development.
Köchl R, Vanes L, Llorian Sopena M, Chakravarty P, Hartweger H, Fountain K, White A, Cowan J, Anderson G, Tybulewicz VL. Köchl R, et al. Among authors: llorian sopena m. Elife. 2020 Oct 14;9:e56934. doi: 10.7554/eLife.56934. Elife. 2020. PMID: 33051000 Free PMC article.