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Novel [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]- 3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2" -dioxide) derivatives with anti-HIV-1 and anti-human-cytomegalovirus activity.
de Castro S, Lobatón E, Pérez-Pérez MJ, San-Félix A, Cordeiro A, Andrei G, Snoeck R, De Clercq E, Balzarini J, Camarasa MJ, Velázquez S. de Castro S, et al. Among authors: lobaton e. J Med Chem. 2005 Feb 24;48(4):1158-68. doi: 10.1021/jm040868q. J Med Chem. 2005. PMID: 15715482
Discovery of TSAO derivatives with an unusual HIV-1 activity/resistance profile.
de Castro S, García-Aparicio C, Van Laethem K, Gago F, Lobatón E, De Clercq E, Balzarini J, Camarasa MJ, Velázquez S. de Castro S, et al. Among authors: lobaton e. Antiviral Res. 2006 Aug;71(1):15-23. doi: 10.1016/j.antiviral.2006.02.009. Epub 2006 Mar 29. Antiviral Res. 2006. PMID: 16616962
Novel series of [ddN]-[TSAO-T] heterodimers as potential bi-functional inhibitors of HIV-1 RT. Studies in the linker and ddN region.
Velázquez S, Tuñón V, Jimeno ML, Pérez-Pérez MJ, San-Félix A, Chamorro C, Lobatón E, Esteban-Gamboa A, De Clercq E, Balzarini J, Camarasa MJ. Velázquez S, et al. Among authors: lobaton e. Nucleosides Nucleotides. 1999 Apr-May;18(4-5):1029-30. doi: 10.1080/15257779908041640. Nucleosides Nucleotides. 1999. PMID: 10432737
Identification of a putative binding site for [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine (TSAO) derivatives at the p51-p66 interface of HIV-1 reverse transcriptase.
Rodríguez-Barrios F, Pérez C, Lobatón E, Velázquez S, Chamorro C, San-Félix A, Pérez-Pérez MJ, Camarasa MJ, Pelemans H, Balzarini J, Gago F. Rodríguez-Barrios F, et al. Among authors: lobaton e. J Med Chem. 2001 Jun 7;44(12):1853-65. doi: 10.1021/jm001095i. J Med Chem. 2001. PMID: 11384232
4"-H-TSAO-T, a novel prototype in the HIV-1 specific TSAO family.
Lobatón E, Velázquez S, San-Félix A, De Clercq E, Balzarini J, Camarasa MJ. Lobatón E, et al. Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):711-4. doi: 10.1081/NCN-100002357. Nucleosides Nucleotides Nucleic Acids. 2001. PMID: 11563098
41 results