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Noncanonical splicing junctions between exons and transposable elements represent a source of immunogenic recurrent neo-antigens in patients with lung cancer.
Merlotti A, Sadacca B, Arribas YA, Ngoma M, Burbage M, Goudot C, Houy A, Rocañín-Arjó A, Lalanne A, Seguin-Givelet A, Lefevre M, Heurtebise-Chrétien S, Baudon B, Oliveira G, Loew D, Carrascal M, Wu CJ, Lantz O, Stern MH, Girard N, Waterfall JJ, Amigorena S. Merlotti A, et al. Among authors: loew d. Sci Immunol. 2023 Feb 3;8(80):eabm6359. doi: 10.1126/sciimmunol.abm6359. Epub 2023 Feb 3. Sci Immunol. 2023. PMID: 36735774
Splicing Patterns in SF3B1-Mutated Uveal Melanoma Generate Shared Immunogenic Tumor-Specific Neoepitopes.
Bigot J, Lalanne AI, Lucibello F, Gueguen P, Houy A, Dayot S, Ganier O, Gilet J, Tosello J, Nemati F, Pierron G, Waterfall JJ, Barnhill R, Gardrat S, Piperno-Neumann S, Popova T, Masson V, Loew D, Mariani P, Cassoux N, Amigorena S, Rodrigues M, Alsafadi S, Stern MH, Lantz O. Bigot J, et al. Among authors: loew d. Cancer Discov. 2021 Aug;11(8):1938-1951. doi: 10.1158/2159-8290.CD-20-0555. Epub 2021 Apr 2. Cancer Discov. 2021. PMID: 33811047
Oncogenic chimeric transcription factors drive tumor-specific transcription, processing, and translation of silent genomic regions.
Vibert J, Saulnier O, Collin C, Petit F, Borgman KJE, Vigneau J, Gautier M, Zaidi S, Pierron G, Watson S, Gruel N, Hénon C, Postel-Vinay S, Deloger M, Raynal V, Baulande S, Laud-Duval K, Hill V, Grossetête S, Dingli F, Loew D, Torrejon J, Ayrault O, Orth MF, Grünewald TGP, Surdez D, Coulon A, Waterfall JJ, Delattre O. Vibert J, et al. Among authors: loew d. Mol Cell. 2022 Jul 7;82(13):2458-2471.e9. doi: 10.1016/j.molcel.2022.04.019. Epub 2022 May 11. Mol Cell. 2022. PMID: 35550257 Free article.
Glycolysis Dependency as a Hallmark of SF3B1-Mutated Cells.
Vivet-Noguer R, Tarin M, Canbezdi C, Dayot S, Silva L, Houy A, Martineau S, Mieulet V, Gentric G, Loew D, Lombard B, Nemati F, Richon S, Guyonnet L, Servois V, Vagner S, Stern MH, Roman-Roman S, Alsafadi S. Vivet-Noguer R, et al. Among authors: loew d. Cancers (Basel). 2022 Apr 24;14(9):2113. doi: 10.3390/cancers14092113. Cancers (Basel). 2022. PMID: 35565242 Free PMC article.
Functional characterization of 5p15.33 risk locus in uveal melanoma reveals rs452384 as a functional variant and NKX2.4 as an allele-specific interactor.
Derrien AC, Houy A, Ganier O, Dingli F, Ningarhari M, Mobuchon L, Espejo Díaz MI, Loew D, Cassoux N, Cussenot O, Cancel-Tassin G, Margueron R, Noirel J, Zucman-Rossi J, Rodrigues M, Stern MH. Derrien AC, et al. Among authors: loew d. Am J Hum Genet. 2022 Dec 1;109(12):2196-2209. doi: 10.1016/j.ajhg.2022.11.004. Am J Hum Genet. 2022. PMID: 36459980 Free PMC article.
Epigenetically controlled tumor antigens derived from splice junctions between exons and transposable elements.
Burbage M, Rocañín-Arjó A, Baudon B, Arribas YA, Merlotti A, Rookhuizen DC, Heurtebise-Chrétien S, Ye M, Houy A, Burgdorf N, Suarez G, Gros M, Sadacca B, Carrascal M, Garmilla A, Bohec M, Baulande S, Lombard B, Loew D, Waterfall JJ, Stern MH, Goudot C, Amigorena S. Burbage M, et al. Among authors: loew d. Sci Immunol. 2023 Feb 3;8(80):eabm6360. doi: 10.1126/sciimmunol.abm6360. Epub 2023 Feb 3. Sci Immunol. 2023. PMID: 36735776
Extracellular vesicles and co-isolated endogenous retroviruses from murine cancer cells differentially affect dendritic cells.
Cocozza F, Martin-Jaular L, Lippens L, Di Cicco A, Arribas YA, Ansart N, Dingli F, Richard M, Merle L, Jouve San Roman M, Poullet P, Loew D, Lévy D, Hendrix A, Kassiotis G, Joliot A, Tkach M, Théry C. Cocozza F, et al. Among authors: loew d. EMBO J. 2023 Dec 11;42(24):e113590. doi: 10.15252/embj.2023113590. EMBO J. 2023. PMID: 38073509 Free PMC article.
Modulating BAP1 expression affects ROS homeostasis, cell motility and mitochondrial function.
Hebert L, Bellanger D, Guillas C, Campagne A, Dingli F, Loew D, Fievet A, Jacquemin V, Popova T, Jean D, Mechta-Grigoriou F, Margueron R, Stern MH. Hebert L, et al. Among authors: loew d. Oncotarget. 2017 Aug 3;8(42):72513-72527. doi: 10.18632/oncotarget.19872. eCollection 2017 Sep 22. Oncotarget. 2017. PMID: 29069806 Free PMC article.
332 results