Longley DB - Search Results

1

Pevonedistat (MLN4924): mechanism of cell death induction and therapeutic potential in colorectal cancer.

Ferris J, Espona-Fiedler M, Hamilton C, Holohan C, Crawford N, McIntyre AJ, Roberts JZ, Wappett M, McDade SS, Longley DB, Coyle V. Ferris J, et al. Among authors: longley db. Cell Death Discov. 2020 Jul 21;6:61. doi: 10.1038/s41420-020-00296-w. eCollection 2020. Cell Death Discov. 2020. PMID: 32714568 Free PMC article.

2

Procaspase 8 overexpression in non-small-cell lung cancer promotes apoptosis induced by FLIP silencing.

Wilson TR, Redmond KM, McLaughlin KM, Crawford N, Gately K, O'Byrne K, Le-Clorrenec C, Holohan C, Fennell DA, Johnston PG, Longley DB. Wilson TR, et al. Among authors: longley db. Cell Death Differ. 2009 Oct;16(10):1352-61. doi: 10.1038/cdd.2009.76. Epub 2009 Jun 19. Cell Death Differ. 2009. PMID: 19543235

3

Prognostic significance of TRAIL signaling molecules in stage II and III colorectal cancer.

McLornan DP, Barrett HL, Cummins R, McDermott U, McDowell C, Conlon SJ, Coyle VM, Van Schaeybroeck S, Wilson R, Kay EW, Longley DB, Johnston PG. McLornan DP, et al. Among authors: longley db. Clin Cancer Res. 2010 Jul 1;16(13):3442-51. doi: 10.1158/1078-0432.CCR-10-0052. Epub 2010 Jun 22. Clin Cancer Res. 2010. PMID: 20570920 Free PMC article.

4

Platinum resistant cancer cells conserve sensitivity to BH3 domains and obatoclax induced mitochondrial apoptosis.

Crawford N, Chacko AD, Savage KI, McCoy F, Redmond K, Longley DB, Fennell DA. Crawford N, et al. Among authors: longley db. Apoptosis. 2011 Mar;16(3):311-20. doi: 10.1007/s10495-010-0561-1. Apoptosis. 2011. PMID: 21107700

5

Vorinostat/SAHA-induced apoptosis in malignant mesothelioma is FLIP/caspase 8-dependent and HR23B-independent.

Hurwitz JL, Stasik I, Kerr EM, Holohan C, Redmond KM, McLaughlin KM, Busacca S, Barbone D, Broaddus VC, Gray SG, O'Byrne KJ, Johnston PG, Fennell DA, Longley DB. Hurwitz JL, et al. Among authors: longley db. Eur J Cancer. 2012 May;48(7):1096-107. doi: 10.1016/j.ejca.2011.11.009. Epub 2011 Dec 10. Eur J Cancer. 2012. PMID: 22154545

6

Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis.

Kerr E, Holohan C, McLaughlin KM, Majkut J, Dolan S, Redmond K, Riley J, McLaughlin K, Stasik I, Crudden M, Van Schaeybroeck S, Fenning C, O'Connor R, Kiely P, Sgobba M, Haigh D, Johnston PG, Longley DB. Kerr E, et al. Among authors: longley db. Cell Death Differ. 2012 Aug;19(8):1317-27. doi: 10.1038/cdd.2012.8. Epub 2012 Feb 10. Cell Death Differ. 2012. PMID: 22322857 Free PMC article.

7

Prognostic and therapeutic relevance of c-FLIP in acute myeloid leukaemia.

McLornan D, Hay J, McLaughlin K, Holohan C, Burnett AK, Hills RK, Johnston PG, Mills KI, McMullin MF, Longley DB, Gilkes A. McLornan D, et al. Among authors: longley db. Br J Haematol. 2013 Jan;160(2):188-98. doi: 10.1111/bjh.12108. Epub 2012 Nov 20. Br J Haematol. 2013. PMID: 23167276 Free article.

8

Acquired differential regulation of caspase-8 in cisplatin-resistant non-small-cell lung cancer.

Paul I, Chacko AD, Stasik I, Busacca S, Crawford N, McCoy F, McTavish N, Wilson B, Barr M, O'Byrne KJ, Longley DB, Fennell DA. Paul I, et al. Among authors: longley db. Cell Death Dis. 2012 Dec 20;3(12):e449. doi: 10.1038/cddis.2012.186. Cell Death Dis. 2012. PMID: 23254292 Free PMC article.

9

SAHA overcomes FLIP-mediated inhibition of SMAC mimetic-induced apoptosis in mesothelioma.

Crawford N, Stasik I, Holohan C, Majkut J, McGrath M, Johnston PG, Chessari G, Ward GA, Waugh DJ, Fennell DA, Longley DB. Crawford N, et al. Among authors: longley db. Cell Death Dis. 2013 Jul 18;4(7):e733. doi: 10.1038/cddis.2013.258. Cell Death Dis. 2013. PMID: 23868066 Free PMC article.

10

Cancer drug resistance: an evolving paradigm.

Holohan C, Van Schaeybroeck S, Longley DB, Johnston PG. Holohan C, et al. Among authors: longley db. Nat Rev Cancer. 2013 Oct;13(10):714-26. doi: 10.1038/nrc3599. Nat Rev Cancer. 2013. PMID: 24060863 Review.

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