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21 results

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Page 1
Lifespan effects in male UM-HET3 mice treated with sodium thiosulfate, 16-hydroxyestriol, and late-start canagliflozin.
Miller RA, Harrison DE, Cortopassi GA, Dehghan I, Fernandez E, Garratt M, Geisler JG, Ginsburg BC, Han ML, Kaczorowski CC, Kumar N, Leiser SF, Lopez-Cruzan M, Milne G, Mitchell JR, Nelson JF, Reifsnyder PC, Salmon AB, Korstanje R, Rosenthal N, Strong R. Miller RA, et al. Among authors: lopez cruzan m. Geroscience. 2024 May 16. doi: 10.1007/s11357-024-01176-2. Online ahead of print. Geroscience. 2024. PMID: 38753230
Evaluation of Exploratory Fluid Biomarker Results from a Phase 1 Senolytic Trial in Mild Alzheimer's Disease.
Garbarino VR, Palavicini JP, Melendez J, Barthelemy N, He Y, Kautz TF, Lopez-Cruzan M, Mathews JJ, Xu P, Zhan B, Saliba A, Ragi N, Sharma K, Craft S, Petersen RC, Espindola-Netto JM, Xue A, Tchkonia T, Kirkland JL, Seshadri S, Salardini A, Musi N, Bateman RJ, Gonzales MM, Orr ME. Garbarino VR, et al. Among authors: lopez cruzan m. Res Sq [Preprint]. 2024 Mar 8:rs.3.rs-3994894. doi: 10.21203/rs.3.rs-3994894/v1. Res Sq. 2024. PMID: 38496619 Free PMC article. Preprint.
A pilot study to investigate the safety and feasibility of antiretroviral therapy for Alzheimer's disease (ART-AD).
Sullivan AC, Zuniga G, Ramirez P, Fernandez R, Wang CP, Li J, Davila L, Pelton K, Gomez S, Sohn C, Gonzalez E, Lopez-Cruzan M, Gonzalez DA, Parker A, Zilli E, de Erausquin GA, Seshadri S, Espinoza S, Musi N, Frost B. Sullivan AC, et al. Among authors: lopez cruzan m. medRxiv [Preprint]. 2024 Feb 28:2024.02.26.24303316. doi: 10.1101/2024.02.26.24303316. medRxiv. 2024. PMID: 38464267 Free PMC article. Preprint.
Feasibility of a telehealth-based contingency management intervention for alcohol use disorders using the phosphatidylethanol (PEth) 16:0/18:1 alcohol biomarker: a pilot randomized trial.
Jett JD, Beck R, Tyutyunnyk D, Sanchez J, Weeks DL, Javors MA, Hill-Kapturczak N, Lopez-Cruzan M, Kriegel L, Ginsburg BC, Cabassa L, McDonell MG. Jett JD, et al. Among authors: lopez cruzan m. Am J Drug Alcohol Abuse. 2024 Mar 3;50(2):162-172. doi: 10.1080/00952990.2023.2283691. Epub 2024 Jan 29. Am J Drug Alcohol Abuse. 2024. PMID: 38284925 Clinical Trial.
Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used.
Harrison DE, Strong R, Reifsnyder P, Rosenthal N, Korstanje R, Fernandez E, Flurkey K, Ginsburg BC, Murrell MD, Javors MA, Lopez-Cruzan M, Nelson JF, Willcox BJ, Allsopp R, Watumull DM, Watumull DG, Cortopassi G, Kirkland JL, Tchkonia T, Choi YG, Yousefzadeh MJ, Robbins PD, Mitchell JR, Acar M, Sarnoski EA, Bene MR, Salmon A, Kumar N, Miller RA. Harrison DE, et al. Among authors: lopez cruzan m. Geroscience. 2024 Feb;46(1):795-816. doi: 10.1007/s11357-023-01011-0. Epub 2023 Dec 2. Geroscience. 2024. PMID: 38041783 Free PMC article.
Senolytic therapy in mild Alzheimer's disease: a phase 1 feasibility trial.
Gonzales MM, Garbarino VR, Kautz TF, Palavicini JP, Lopez-Cruzan M, Dehkordi SK, Mathews JJ, Zare H, Xu P, Zhang B, Franklin C, Habes M, Craft S, Petersen RC, Tchkonia T, Kirkland JL, Salardini A, Seshadri S, Musi N, Orr ME. Gonzales MM, et al. Among authors: lopez cruzan m. Nat Med. 2023 Oct;29(10):2481-2488. doi: 10.1038/s41591-023-02543-w. Epub 2023 Sep 7. Nat Med. 2023. PMID: 37679434 Free PMC article. Clinical Trial.
Senolytic therapy to modulate the progression of Alzheimer's Disease (SToMP-AD) - Outcomes from the first clinical trial of senolytic therapy for Alzheimer's disease.
Gonzales MM, Garbarino VR, Kautz T, Palavicini JP, Lopez-Cruzan M, Dehkordi SK, Mathews J, Zare H, Xu P, Zhang B, Franklin C, Habes M, Craft S, Petersen RC, Tchkonia T, Kirkland J, Salardini A, Seshadri S, Musi N, Orr ME. Gonzales MM, et al. Among authors: lopez cruzan m. Res Sq [Preprint]. 2023 Apr 24:rs.3.rs-2809973. doi: 10.21203/rs.3.rs-2809973/v1. Res Sq. 2023. PMID: 37162971 Free PMC article. Updated. Preprint.
Lifespan benefits for the combination of rapamycin plus acarbose and for captopril in genetically heterogeneous mice.
Strong R, Miller RA, Cheng CJ, Nelson JF, Gelfond J, Allani SK, Diaz V, Dorigatti AO, Dorigatti J, Fernandez E, Galecki A, Ginsburg B, Hamilton KL, Javors MA, Kornfeld K, Kaeberlein M, Kumar S, Lombard DB, Lopez-Cruzan M, Miller BF, Rabinovitch P, Reifsnyder P, Rosenthal NA, Bogue MA, Salmon AB, Suh Y, Verdin E, Weissbach H, Newman J, Maccchiarini F, Harrison DE. Strong R, et al. Among authors: lopez cruzan m. Aging Cell. 2022 Dec;21(12):e13724. doi: 10.1111/acel.13724. Epub 2022 Sep 30. Aging Cell. 2022. PMID: 36179270 Free PMC article.
San Antonio Nathan Shock Center: your one-stop shop for aging research.
Salmon AB, Nelson JF, Gelfond JAL, Javors M, Ginsburg B, Lopez-Cruzan M, Galvan V, Fernandez E, Musi N, Ikeno Y, Hubbard G, Lechleiter J, Hornsby PJ, Strong R. Salmon AB, et al. Among authors: lopez cruzan m. Geroscience. 2021 Oct;43(5):2105-2118. doi: 10.1007/s11357-021-00417-y. Epub 2021 Jul 9. Geroscience. 2021. PMID: 34240333 Free PMC article.
21 results