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Immunotherapy targeting the C-terminal domain of TDP-43 decreases neuropathology and confers neuroprotection in mouse models of ALS/FTD.
Afroz T, Chevalier E, Audrain M, Dumayne C, Ziehm T, Moser R, Egesipe AL, Mottier L, Ratnam M, Neumann M, Havas D, Ollier R, Piorkowska K, Chauhan M, Silva AB, Thapa S, Stöhr J, Bavdek A, Eligert V, Adolfsson O, Nelson PT, Porta S, Lee VM, Pfeifer A, Kosco-Vilbois M, Seredenina T. Afroz T, et al. Among authors: mottier l. Neurobiol Dis. 2023 Apr;179:106050. doi: 10.1016/j.nbd.2023.106050. Epub 2023 Feb 20. Neurobiol Dis. 2023. PMID: 36809847 Free article.
Targeting amyotrophic lateral sclerosis by neutralizing seeding-competent TDP-43 in CSF.
Audrain M, Egesipe AL, Tentillier N, Font L, Ratnam M, Mottier L, Clavel M, Le Roux-Bourdieu M, Fenyi A, Ollier R, Chevalier E, Guilhot F, Fuchs A, Piorkowska K, Carlyle B, Arnold SE, Berry JD, Luthi-Carter R, Adolfsson O, Pfeifer A, Kosco-Vilbois M, Seredenina T, Afroz T. Audrain M, et al. Among authors: mottier l. Brain Commun. 2023 Nov 3;5(6):fcad306. doi: 10.1093/braincomms/fcad306. eCollection 2023. Brain Commun. 2023. PMID: 38025276 Free PMC article.
An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of α-synuclein.
Kara E, Crimi A, Wiedmer A, Emmenegger M, Manzoni C, Bandres-Ciga S, D'Sa K, Reynolds RH, Botía JA, Losa M, Lysenko V, Carta M, Heinzer D, Avar M, Chincisan A, Blauwendraat C, García-Ruiz S, Pease D, Mottier L, Carrella A, Beck-Schneider D, Magalhães AD, Aemisegger C, Theocharides APA, Fan Z, Marks JD, Hopp SC, Abramov AY, Lewis PA, Ryten M, Hardy J, Hyman BT, Aguzzi A. Kara E, et al. Among authors: mottier l. Cell Rep. 2021 Jun 8;35(10):109189. doi: 10.1016/j.celrep.2021.109189. Cell Rep. 2021. PMID: 34107263 Free PMC article.