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Tripartite motif 24 (Trim24/Tif1α) tumor suppressor protein is a novel negative regulator of interferon (IFN)/signal transducers and activators of transcription (STAT) signaling pathway acting through retinoic acid receptor α (Rarα) inhibition.
Tisserand J, Khetchoumian K, Thibault C, Dembélé D, Chambon P, Losson R. Tisserand J, et al. Among authors: losson r. J Biol Chem. 2011 Sep 23;286(38):33369-79. doi: 10.1074/jbc.M111.225680. Epub 2011 Jul 18. J Biol Chem. 2011. PMID: 21768647 Free PMC article.
Retinoic acid induces TGFbeta-dependent autocrine fibroblast growth.
Fadloun A, Kobi D, Delacroix L, Dembélé D, Michel I, Lardenois A, Tisserand J, Losson R, Mengus G, Davidson I. Fadloun A, et al. Among authors: losson r. Oncogene. 2008 Jan 17;27(4):477-89. doi: 10.1038/sj.onc.1210657. Epub 2007 Jul 16. Oncogene. 2008. PMID: 17637747
Transcription cofactors TRIM24, TRIM28, and TRIM33 associate to form regulatory complexes that suppress murine hepatocellular carcinoma.
Herquel B, Ouararhni K, Khetchoumian K, Ignat M, Teletin M, Mark M, Béchade G, Van Dorsselaer A, Sanglier-Cianférani S, Hamiche A, Cammas F, Davidson I, Losson R. Herquel B, et al. Among authors: losson r. Proc Natl Acad Sci U S A. 2011 May 17;108(20):8212-7. doi: 10.1073/pnas.1101544108. Epub 2011 Apr 29. Proc Natl Acad Sci U S A. 2011. PMID: 21531907 Free PMC article.
TRIM involvement in transcriptional regulation.
Cammas F, Khetchoumian K, Chambon P, Losson R. Cammas F, et al. Among authors: losson r. Adv Exp Med Biol. 2012;770:59-76. doi: 10.1007/978-1-4614-5398-7_5. Adv Exp Med Biol. 2012. PMID: 23631000 Review.
90 results