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REVERBa couples the circadian clock to hepatic glucocorticoid action.
Caratti G, Iqbal M, Hunter L, Kim D, Wang P, Vonslow RM, Begley N, Tetley AJ, Woodburn JL, Pariollaud M, Maidstone R, Donaldson IJ, Zhang Z, Ince LM, Kitchen G, Baxter M, Poolman TM, Daniels DA, Stirling DR, Brocker C, Gonzalez F, Loudon AS, Bechtold DA, Rattray M, Matthews LC, Ray DW. Caratti G, et al. Among authors: loudon as. J Clin Invest. 2018 Oct 1;128(10):4454-4471. doi: 10.1172/JCI96138. Epub 2018 Sep 4. J Clin Invest. 2018. PMID: 30179226 Free PMC article.
Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation.
Pariollaud M, Gibbs JE, Hopwood TW, Brown S, Begley N, Vonslow R, Poolman T, Guo B, Saer B, Jones DH, Tellam JP, Bresciani S, Tomkinson NC, Wojno-Picon J, Cooper AW, Daniels DA, Trump RP, Grant D, Zuercher W, Willson TM, MacDonald AS, Bolognese B, Podolin PL, Sanchez Y, Loudon AS, Ray DW. Pariollaud M, et al. Among authors: loudon as. J Clin Invest. 2018 Jun 1;128(6):2281-2296. doi: 10.1172/JCI93910. Epub 2018 Apr 30. J Clin Invest. 2018. PMID: 29533925 Free PMC article.
Circadian variation in pulmonary inflammatory responses is independent of rhythmic glucocorticoid signaling in airway epithelial cells.
Ince LM, Zhang Z, Beesley S, Vonslow RM, Saer BR, Matthews LC, Begley N, Gibbs JE, Ray DW, Loudon ASI. Ince LM, et al. FASEB J. 2019 Jan;33(1):126-139. doi: 10.1096/fj.201800026RR. Epub 2018 Jul 2. FASEB J. 2019. PMID: 29965797 Free PMC article.
However, deletion of GR in the bronchial epithelium blocked rhythmic CXCL5 production, identifying GR as required to confer circadian control to CXCL5. Surprisingly, rhythmic pulmonary neutrophilia persisted, despite nonrhythmic CXCL5 responses, indicating additional circa …
However, deletion of GR in the bronchial epithelium blocked rhythmic CXCL5 production, identifying GR as required to confer circadian …
HNF4A modulates glucocorticoid action in the liver.
Hunter AL, Poolman TM, Kim D, Gonzalez FJ, Bechtold DA, Loudon ASI, Iqbal M, Ray DW. Hunter AL, et al. Among authors: loudon asi. Cell Rep. 2022 Apr 19;39(3):110697. doi: 10.1016/j.celrep.2022.110697. Cell Rep. 2022. PMID: 35443180 Free PMC article.
The circadian clock and asthma.
Durrington HJ, Farrow SN, Loudon AS, Ray DW. Durrington HJ, et al. Among authors: loudon as. Thorax. 2014 Jan;69(1):90-2. doi: 10.1136/thoraxjnl-2013-203482. Epub 2013 May 23. Thorax. 2014. PMID: 23704227
168 results