Lu J - Search Results

1

A copper(II)-selective chelator ameliorates diabetes-evoked renal fibrosis and albuminuria, and suppresses pathogenic TGF-beta activation in the kidneys of rats used as a model of diabetes.

Gong D, Lu J, Chen X, Reddy S, Crossman DJ, Glyn-Jones S, Choong YS, Kennedy J, Barry B, Zhang S, Chan YK, Ruggiero K, Phillips AR, Cooper GJ. Gong D, et al. Among authors: lu j. Diabetologia. 2008 Sep;51(9):1741-51. doi: 10.1007/s00125-008-1088-7. Epub 2008 Jul 18. Diabetologia. 2008. PMID: 18636238

2

Molecular changes evoked by triethylenetetramine treatment in the extracellular matrix of the heart and aorta in diabetic rats.

Gong D, Lu J, Chen X, Choong SY, Zhang S, Chan YK, Glyn-Jones S, Gamble GD, Phillips AR, Cooper GJ. Gong D, et al. Among authors: lu j. Mol Pharmacol. 2006 Dec;70(6):2045-51. doi: 10.1124/mol.106.028605. Epub 2006 Sep 14. Mol Pharmacol. 2006. PMID: 16973718

3

Triethylenetetramine and metabolites: levels in relation to copper and zinc excretion in urine of healthy volunteers and type 2 diabetic patients.

Lu J, Chan YK, Gamble GD, Poppitt SD, Othman AA, Cooper GJ. Lu J, et al. Drug Metab Dispos. 2007 Feb;35(2):221-7. doi: 10.1124/dmd.106.012922. Epub 2006 Nov 15. Drug Metab Dispos. 2007. PMID: 17108057

4

Determination of triethylenetetramine (TETA) and its metabolites in human plasma and urine by liquid chromatography-mass spectrometry (LC-MS).

Lu J, Chan YK, Poppitt SD, Cooper GJ. Lu J, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Nov 1;859(1):62-8. doi: 10.1016/j.jchromb.2007.09.001. Epub 2007 Sep 14. J Chromatogr B Analyt Technol Biomed Life Sci. 2007. PMID: 17901001

5

Development and validation of a rapid HPLC method for the simultaneous determination of triethylenetetramine and its two main metabolites in human serum.

Othman A, Lu J, Sunderland T, Cooper GJ. Othman A, et al. Among authors: lu j. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Dec 1;860(1):42-8. doi: 10.1016/j.jchromb.2007.10.006. Epub 2007 Oct 10. J Chromatogr B Analyt Technol Biomed Life Sci. 2007. PMID: 17980682

6

Quantitative proteomic profiling identifies new renal targets of copper(II)-selective chelation in the reversal of diabetic nephropathy in rats.

Gong D, Chen X, Middleditch M, Huang L, Vazhoor Amarsingh G, Reddy S, Lu J, Zhang S, Ruggiero K, Phillips AR, Cooper GJ. Gong D, et al. Among authors: lu j. Proteomics. 2009 Sep;9(18):4309-20. doi: 10.1002/pmic.200900285. Proteomics. 2009. PMID: 19634143

7

Pharmacokinetics, pharmacodynamics, and metabolism of triethylenetetramine in healthy human participants: an open-label trial.

Lu J, Poppitt SD, Othman AA, Sunderland T, Ruggiero K, Willett MS, Diamond LE, Garcia WD, Roesch BG, Cooper GJ. Lu J, et al. J Clin Pharmacol. 2010 Jun;50(6):647-58. doi: 10.1177/0091270009349379. Epub 2010 Feb 9. J Clin Pharmacol. 2010. PMID: 20145262 Clinical Trial.

8

Copper(II)-selective chelation improves function and antioxidant defences in cardiovascular tissues of rats as a model of diabetes: comparisons between triethylenetetramine and three less copper-selective transition-metal-targeted treatments.

Lu J, Gong D, Choong SY, Xu H, Chan YK, Chen X, Fitzpatrick S, Glyn-Jones S, Zhang S, Nakamura T, Ruggiero K, Obolonkin V, Poppitt SD, Phillips AR, Cooper GJ. Lu J, et al. Diabetologia. 2010 Jun;53(6):1217-26. doi: 10.1007/s00125-010-1698-8. Epub 2010 Mar 11. Diabetologia. 2010. PMID: 20221822

9

Triethylenetetramine pharmacology and its clinical applications.

Lu J. Lu J. Mol Cancer Ther. 2010 Sep;9(9):2458-67. doi: 10.1158/1535-7163.MCT-10-0523. Epub 2010 Jul 26. Mol Cancer Ther. 2010. PMID: 20660601 Review.

10

Illuminating the molecular basis of diabetic arteriopathy: a proteomic comparison of aortic tissue from diabetic and healthy rats.

Jüllig M, Chen X, Middleditch MJ, Vazhoor G, Hickey AJ, Gong D, Lu J, Zhang S, Phillips AR, Cooper GJ. Jüllig M, et al. Among authors: lu j. Proteomics. 2010 Sep;10(18):3367-78. doi: 10.1002/pmic.201000276. Proteomics. 2010. PMID: 20707005

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