Lu S - Search Results

1

An active site loop toggles between conformations to control antibiotic hydrolysis and inhibition potency for CTX-M β-lactamase drug-resistance enzymes.

Lu S, Hu L, Lin H, Judge A, Rivera P, Palaniappan M, Sankaran B, Wang J, Prasad BVV, Palzkill T. Lu S, et al. Nat Commun. 2022 Nov 7;13(1):6726. doi: 10.1038/s41467-022-34564-3. Nat Commun. 2022. PMID: 36344533 Free PMC article.

2

Development and Evaluation of a Novel Protein-Based Assay for Specific Detection of KPC β-Lactamases from Klebsiella pneumoniae Clinical Isolates.

Lu S, Soeung V, Nguyen HAT, Long SW, Musser JM, Palzkill T. Lu S, et al. mSphere. 2020 Jan 8;5(1):e00918-19. doi: 10.1128/mSphere.00918-19. mSphere. 2020. PMID: 31915233 Free PMC article.

3

A drug-resistant β-lactamase variant changes the conformation of its active-site proton shuttle to alter substrate specificity and inhibitor potency.

Soeung V, Lu S, Hu L, Judge A, Sankaran B, Prasad BVV, Palzkill T. Soeung V, et al. Among authors: lu s. J Biol Chem. 2020 Dec 25;295(52):18239-18255. doi: 10.1074/jbc.RA120.016103. Epub 2020 Oct 26. J Biol Chem. 2020. PMID: 33109613 Free article.

4

[No title available]

[No authors listed] [No authors listed] PMID: 33453830

5

DNA-encoded chemistry technology yields expedient access to SARS-CoV-2 M^pro inhibitors.

Chamakuri S, Lu S, Ucisik MN, Bohren KM, Chen YC, Du HC, Faver JC, Jimmidi R, Li F, Li JY, Nyshadham P, Palmer SS, Pollet J, Qin X, Ronca SE, Sankaran B, Sharma KL, Tan Z, Versteeg L, Yu Z, Matzuk MM, Palzkill T, Young DW. Chamakuri S, et al. Among authors: lu s. Proc Natl Acad Sci U S A. 2021 Sep 7;118(36):e2111172118. doi: 10.1073/pnas.2111172118. Proc Natl Acad Sci U S A. 2021. PMID: 34426525 Free PMC article.

6

Mutagenesis and structural analysis reveal the CTX-M β-lactamase active site is optimized for cephalosporin catalysis and drug resistance.

Lu S, Montoya M, Hu L, Neetu N, Sankaran B, Prasad BVV, Palzkill T. Lu S, et al. J Biol Chem. 2023 May;299(5):104630. doi: 10.1016/j.jbc.2023.104630. Epub 2023 Mar 22. J Biol Chem. 2023. PMID: 36963495 Free PMC article.

7

DNA-encoded chemical libraries yield non-covalent and non-peptidic SARS-CoV-2 main protease inhibitors.

Jimmidi R, Chamakuri S, Lu S, Ucisik MN, Chen PJ, Bohren KM, Moghadasi SA, Versteeg L, Nnabuife C, Li JY, Qin X, Chen YC, Faver JC, Nyshadham P, Sharma KL, Sankaran B, Judge A, Yu Z, Li F, Pollet J, Harris RS, Matzuk MM, Palzkill T, Young DW. Jimmidi R, et al. Among authors: lu s. Commun Chem. 2023 Aug 4;6(1):164. doi: 10.1038/s42004-023-00961-y. Commun Chem. 2023. PMID: 37542196 Free PMC article.

8

Intracellular Ca²⁺ regulation of H⁺/Ca²⁺ antiporter YfkE mediated by a Ca²⁺ mini-sensor.

Lu S, Li Z, Gorfe AA, Zheng L. Lu S, et al. Proc Natl Acad Sci U S A. 2020 May 12;117(19):10313-10321. doi: 10.1073/pnas.1918604117. Epub 2020 Apr 27. Proc Natl Acad Sci U S A. 2020. PMID: 32341169 Free PMC article.

9

Structural Insight into Substrate Selection and Catalysis of Lipid Phosphate Phosphatase PgpB in the Cell Membrane.

Tong S, Lin Y, Lu S, Wang M, Bogdanov M, Zheng L. Tong S, et al. Among authors: lu s. J Biol Chem. 2016 Aug 26;291(35):18342-52. doi: 10.1074/jbc.M116.737874. Epub 2016 Jul 12. J Biol Chem. 2016. PMID: 27405756 Free PMC article.

10

Ca²⁺ efflux facilitated by co-transport of inorganic phosphate anion in the H⁺/Ca²⁺ antiporter YfkE.

Niu W, Zhou W, Lu S, Vu T, Jayaraman V, Faraldo-Gómez JD, Zheng L. Niu W, et al. Among authors: lu s. Commun Biol. 2023 May 29;6(1):573. doi: 10.1038/s42003-023-04944-6. Commun Biol. 2023. PMID: 37248347 Free PMC article.

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