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Epigenetic plasticity cooperates with cell-cell interactions to direct pancreatic tumorigenesis.
Burdziak C, Alonso-Curbelo D, Walle T, Reyes J, Barriga FM, Haviv D, Xie Y, Zhao Z, Zhao CJ, Chen HA, Chaudhary O, Masilionis I, Choo ZN, Gao V, Luan W, Wuest A, Ho YJ, Wei Y, Quail DF, Koche R, Mazutis L, Chaligné R, Nawy T, Lowe SW, Pe'er D. Burdziak C, et al. Among authors: luan w. Science. 2023 May 12;380(6645):eadd5327. doi: 10.1126/science.add5327. Epub 2023 May 12. Science. 2023. PMID: 37167403 Free PMC article.
Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity.
Chen HA, Ho YJ, Mezzadra R, Adrover JM, Smolkin R, Zhu C, Woess K, Bernstein N, Schmitt G, Fong L, Luan W, Wuest A, Tian S, Li X, Broderick C, Hendrickson RC, Egeblad M, Chen Z, Alonso-Curbelo D, Lowe SW. Chen HA, et al. Among authors: luan w. Cancer Discov. 2023 Feb 6;13(2):432-453. doi: 10.1158/2159-8290.CD-22-0528. Cancer Discov. 2023. PMID: 36302222 Free PMC article.
EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype to potentiate pancreatic cancer immune surveillance.
Chibaya L, Murphy KC, DeMarco KD, Gopalan S, Liu H, Parikh CN, Lopez-Diaz Y, Faulkner M, Li J, Morris JP 4th, Ho YJ, Chana SK, Simon J, Luan W, Kulick A, de Stanchina E, Simin K, Zhu LJ, Fazzio TG, Lowe SW, Ruscetti M. Chibaya L, et al. Among authors: luan w. Nat Cancer. 2023 Jun;4(6):872-892. doi: 10.1038/s43018-023-00553-8. Epub 2023 May 4. Nat Cancer. 2023. PMID: 37142692 Free PMC article.
Generation of precision preclinical cancer models using regulated in vivo base editing.
Katti A, Vega-Pérez A, Foronda M, Zimmerman J, Zafra MP, Granowsky E, Goswami S, Gardner EE, Diaz BJ, Simon JM, Wuest A, Luan W, Fernandez MTC, Kadina AP, Walker JA 2nd, Holden K, Lowe SW, Sánchez Rivera FJ, Dow LE. Katti A, et al. Among authors: luan w. Nat Biotechnol. 2024 Mar;42(3):437-447. doi: 10.1038/s41587-023-01900-x. Epub 2023 Aug 10. Nat Biotechnol. 2024. PMID: 37563300
Metastatic site influences driver gene function in pancreatic cancer.
Tsanov KM, Barriga FM, Ho YJ, Alonso-Curbelo D, Livshits G, Koche RP, Baslan T, Simon J, Tian S, Wuest AN, Luan W, Wilkinson JE, Masilionis I, Dimitrova N, Iacobuzio-Donahue CA, Chaligné R, Pe'er D, Massagué J, Lowe SW. Tsanov KM, et al. Among authors: luan w. bioRxiv [Preprint]. 2024 Mar 18:2024.03.17.585402. doi: 10.1101/2024.03.17.585402. bioRxiv. 2024. PMID: 38562717 Free PMC article. Preprint.
271 results