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The endocannabinoid system dual-target ligand N-cycloheptyl-1,2-dihydro-5-bromo-1-(4-fluorobenzyl)-6-methyl-2-oxo-pyridine-3-carboxamide improves disease severity in a mouse model of multiple sclerosis.
Arena C, Gado F, Di Cesare Mannelli L, Cervetto C, Carpi S, Reynoso-Moreno I, Polini B, Vallini E, Chicca S, Lucarini E, Bertini S, D'Andrea F, Digiacomo M, Poli G, Tuccinardi T, Macchia M, Gertsch J, Marcoli M, Nieri P, Ghelardini C, Chicca A, Manera C. Arena C, et al. Among authors: lucarini e. Eur J Med Chem. 2020 Dec 15;208:112858. doi: 10.1016/j.ejmech.2020.112858. Epub 2020 Sep 29. Eur J Med Chem. 2020. PMID: 33002735
Effects of natural and synthetic isothiocyanate-based H2S-releasers against chemotherapy-induced neuropathic pain: Role of Kv7 potassium channels.
Di Cesare Mannelli L, Lucarini E, Micheli L, Mosca I, Ambrosino P, Soldovieri MV, Martelli A, Testai L, Taglialatela M, Calderone V, Ghelardini C. Di Cesare Mannelli L, et al. Among authors: lucarini e. Neuropharmacology. 2017 Jul 15;121:49-59. doi: 10.1016/j.neuropharm.2017.04.029. Epub 2017 Apr 19. Neuropharmacology. 2017. PMID: 28431970
Identification of the First Synthetic Allosteric Modulator of the CB2 Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief.
Gado F, Di Cesare Mannelli L, Lucarini E, Bertini S, Cappelli E, Digiacomo M, Stevenson LA, Macchia M, Tuccinardi T, Ghelardini C, Pertwee RG, Manera C. Gado F, et al. Among authors: lucarini e. J Med Chem. 2019 Jan 10;62(1):276-287. doi: 10.1021/acs.jmedchem.8b00368. Epub 2018 Jul 23. J Med Chem. 2019. PMID: 29990428
76 results