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Lck bound to coreceptor is less active than free Lck.
Wei Q, Brzostek J, Sankaran S, Casas J, Hew LS, Yap J, Zhao X, Wojciech L, Gascoigne NRJ. Wei Q, et al. Among authors: wojciech l. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15809-15817. doi: 10.1073/pnas.1913334117. Epub 2020 Jun 22. Proc Natl Acad Sci U S A. 2020. PMID: 32571924 Free PMC article.
Canonical T cell receptor docking on peptide-MHC is essential for T cell signaling.
Zareie P, Szeto C, Farenc C, Gunasinghe SD, Kolawole EM, Nguyen A, Blyth C, Sng XYX, Li J, Jones CM, Fulcher AJ, Jacobs JR, Wei Q, Wojciech L, Petersen J, Gascoigne NRJ, Evavold BD, Gaus K, Gras S, Rossjohn J, La Gruta NL. Zareie P, et al. Among authors: wojciech l. Science. 2021 Jun 4;372(6546):eabe9124. doi: 10.1126/science.abe9124. Science. 2021. PMID: 34083463
18 results