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Methylome-based cell-of-origin modeling (Methyl-COOM) identifies aberrant expression of immune regulatory molecules in CLL.
Wierzbinska JA, Toth R, Ishaque N, Rippe K, Mallm JP, Klett LC, Mertens D, Zenz T, Hielscher T, Seifert M, Küppers R, Assenov Y, Lutsik P, Stilgenbauer S, Roessner PM, Seiffert M, Byrd J, Oakes CC, Plass C, Lipka DB. Wierzbinska JA, et al. Among authors: lutsik p. Genome Med. 2020 Mar 18;12(1):29. doi: 10.1186/s13073-020-00724-7. Genome Med. 2020. PMID: 32188505 Free PMC article.
Comprehensive analysis of DNA methylation data with RnBeads.
Assenov Y, Müller F, Lutsik P, Walter J, Lengauer T, Bock C. Assenov Y, et al. Among authors: lutsik p. Nat Methods. 2014 Nov;11(11):1138-1140. doi: 10.1038/nmeth.3115. Epub 2014 Sep 28. Nat Methods. 2014. PMID: 25262207 Free PMC article.
From Basic Knowledge to Effective Therapies.
Lipka DB, Lutsik P, Plass C. Lipka DB, et al. Among authors: lutsik p. Cancer Cell. 2018 Dec 10;34(6):871-873. doi: 10.1016/j.ccell.2018.11.013. Cancer Cell. 2018. PMID: 30537508 Free article.
Molecular Evolution of Early-Onset Prostate Cancer Identifies Molecular Risk Markers and Clinical Trajectories.
Gerhauser C, Favero F, Risch T, Simon R, Feuerbach L, Assenov Y, Heckmann D, Sidiropoulos N, Waszak SM, Hübschmann D, Urbanucci A, Girma EG, Kuryshev V, Klimczak LJ, Saini N, Stütz AM, Weichenhan D, Böttcher LM, Toth R, Hendriksen JD, Koop C, Lutsik P, Matzk S, Warnatz HJ, Amstislavskiy V, Feuerstein C, Raeder B, Bogatyrova O, Schmitz EM, Hube-Magg C, Kluth M, Huland H, Graefen M, Lawerenz C, Henry GH, Yamaguchi TN, Malewska A, Meiners J, Schilling D, Reisinger E, Eils R, Schlesner M, Strand DW, Bristow RG, Boutros PC, von Kalle C, Gordenin D, Sültmann H, Brors B, Sauter G, Plass C, Yaspo ML, Korbel JO, Schlomm T, Weischenfeldt J. Gerhauser C, et al. Among authors: lutsik p. Cancer Cell. 2018 Dec 10;34(6):996-1011.e8. doi: 10.1016/j.ccell.2018.10.016. Cancer Cell. 2018. PMID: 30537516 Free PMC article.
Integrative Analysis Defines Distinct Prognostic Subgroups of Intrahepatic Cholangiocarcinoma.
Goeppert B, Toth R, Singer S, Albrecht T, Lipka DB, Lutsik P, Brocks D, Baehr M, Muecke O, Assenov Y, Gu L, Endris V, Stenzinger A, Mehrabi A, Schirmacher P, Plass C, Weichenhan D, Roessler S. Goeppert B, et al. Among authors: lutsik p. Hepatology. 2019 May;69(5):2091-2106. doi: 10.1002/hep.30493. Epub 2019 Feb 28. Hepatology. 2019. PMID: 30615206 Free PMC article.
Enhancer hijacking activates oncogenic transcription factor NR4A3 in acinic cell carcinomas of the salivary glands.
Haller F, Bieg M, Will R, Körner C, Weichenhan D, Bott A, Ishaque N, Lutsik P, Moskalev EA, Mueller SK, Bähr M, Woerner A, Kaiser B, Scherl C, Haderlein M, Kleinheinz K, Fietkau R, Iro H, Eils R, Hartmann A, Plass C, Wiemann S, Agaimy A. Haller F, et al. Among authors: lutsik p. Nat Commun. 2019 Jan 21;10(1):368. doi: 10.1038/s41467-018-08069-x. Nat Commun. 2019. PMID: 30664630 Free PMC article.
RnBeads 2.0: comprehensive analysis of DNA methylation data.
Müller F, Scherer M, Assenov Y, Lutsik P, Walter J, Lengauer T, Bock C. Müller F, et al. Among authors: lutsik p. Genome Biol. 2019 Mar 14;20(1):55. doi: 10.1186/s13059-019-1664-9. Genome Biol. 2019. PMID: 30871603 Free PMC article.
Neuronal ensemble-specific DNA methylation strengthens engram stability.
Gulmez Karaca K, Kupke J, Brito DVC, Zeuch B, Thome C, Weichenhan D, Lutsik P, Plass C, Oliveira AMM. Gulmez Karaca K, et al. Among authors: lutsik p. Nat Commun. 2020 Jan 31;11(1):639. doi: 10.1038/s41467-020-14498-4. Nat Commun. 2020. PMID: 32005851 Free PMC article.
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