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Page 1
Advances in covalent drug discovery.
Nat Rev Drug Discov. 2022 Dec;21(12):881-898. doi: 10.1038/s41573-022-00542-z. Epub 2022 Aug 25.
Nat Rev Drug Discov. 2022.
PMID: 36008483
Free PMC article.
Review.
Deubiquitinase-targeting chimeras for targeted protein stabilization.
Henning NJ, Boike L, Spradlin JN, Ward CC, Liu G, Zhang E, Belcher BP, Brittain SM, Hesse MJ, Dovala D, McGregor LM, Valdez Misiolek R, Plasschaert LW, Rowlands DJ, Wang F, Frank AO, Fuller D, Estes AR, Randal KL, Panidapu A, McKenna JM, Tallarico JA, Schirle M, Nomura DK.
Henning NJ, et al. Among authors: boike l.
Nat Chem Biol. 2022 Apr;18(4):412-421. doi: 10.1038/s41589-022-00971-2. Epub 2022 Feb 24.
Nat Chem Biol. 2022.
PMID: 35210618
Free PMC article.
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Discovery of a Functional Covalent Ligand Targeting an Intrinsically Disordered Cysteine within MYC.
Boike L, Cioffi AG, Majewski FC, Co J, Henning NJ, Jones MD, Liu G, McKenna JM, Tallarico JA, Schirle M, Nomura DK.
Boike L, et al.
Cell Chem Biol. 2021 Jan 21;28(1):4-13.e17. doi: 10.1016/j.chembiol.2020.09.001. Epub 2020 Sep 22.
Cell Chem Biol. 2021.
PMID: 32966806
Free PMC article.
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Tyrosinase-Mediated Synthesis of Nanobody-Cell Conjugates.
Maza JC, García-Almedina DM, Boike LE, Hamlish NX, Nomura DK, Francis MB.
Maza JC, et al. Among authors: boike le.
ACS Cent Sci. 2022 Jul 27;8(7):955-962. doi: 10.1021/acscentsci.1c01265. Epub 2022 Jun 22.
ACS Cent Sci. 2022.
PMID: 35912347
Free PMC article.
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Discovery of Potent Pyrazoline-Based Covalent SARS-CoV-2 Main Protease Inhibitors.
Moon P, Zammit CM, Shao Q, Dovala D, Boike L, Henning NJ, Knapp M, Spradlin JN, Ward CC, Wolleb H, Fuller D, Blake G, Murphy JP, Wang F, Lu Y, Moquin SA, Tandeske L, Hesse MJ, McKenna JM, Tallarico JA, Schirle M, Toste FD, Nomura DK.
Moon P, et al. Among authors: boike l.
Chembiochem. 2023 Jun 1;24(11):e202300116. doi: 10.1002/cbic.202300116. Epub 2023 May 3.
Chembiochem. 2023.
PMID: 37069799
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A covalent inhibitor targeting the papain-like protease from SARS-CoV-2 inhibits viral replication.
Han H, Gracia AV, Røise JJ, Boike L, Leon K, Schulze-Gahmen U, Stentzel MR, Bajaj T, Chen D, Li IC, He M, Behrouzi K, Khodabakhshi Z, Nomura DK, Mofrad MRK, Kumar GR, Ott M, Murthy N.
Han H, et al. Among authors: boike l.
RSC Adv. 2023 Apr 4;13(16):10636-10641. doi: 10.1039/d3ra00426k. eCollection 2023 Apr 3.
RSC Adv. 2023.
PMID: 37025664
Free PMC article.
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Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function.
Luo M, Spradlin JN, Boike L, Tong B, Brittain SM, McKenna JM, Tallarico JA, Schirle M, Maimone TJ, Nomura DK.
Luo M, et al. Among authors: boike l.
Cell Chem Biol. 2021 Apr 15;28(4):559-566.e15. doi: 10.1016/j.chembiol.2021.01.005. Epub 2021 Jan 28.
Cell Chem Biol. 2021.
PMID: 33513350
Free PMC article.
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