Lynch EM - Search Results

1

Selective activation of PFKL suppresses the phagocytic oxidative burst.

Amara N, Cooper MP, Voronkova MA, Webb BA, Lynch EM, Kollman JM, Ma T, Yu K, Lai Z, Sangaraju D, Kayagaki N, Newton K, Bogyo M, Staben ST, Dixit VM. Amara N, et al. Among authors: lynch em. Cell. 2021 Aug 19;184(17):4480-4494.e15. doi: 10.1016/j.cell.2021.07.004. Epub 2021 Jul 27. Cell. 2021. PMID: 34320407 Free PMC article.

2

The tetrameric kinesin Kif25 suppresses pre-mitotic centrosome separation to establish proper spindle orientation.

Decarreau J, Wagenbach M, Lynch E, Halpern AR, Vaughan JC, Kollman J, Wordeman L. Decarreau J, et al. Nat Cell Biol. 2017 Apr;19(4):384-390. doi: 10.1038/ncb3486. Epub 2017 Mar 6. Nat Cell Biol. 2017. PMID: 28263957 Free PMC article.

3

Human CTP synthase filament structure reveals the active enzyme conformation.

Lynch EM, Hicks DR, Shepherd M, Endrizzi JA, Maker A, Hansen JM, Barry RM, Gitai Z, Baldwin EP, Kollman JM. Lynch EM, et al. Nat Struct Mol Biol. 2017 Jun;24(6):507-514. doi: 10.1038/nsmb.3407. Epub 2017 May 1. Nat Struct Mol Biol. 2017. PMID: 28459447 Free PMC article.

4

Corrigendum: The tetrameric kinesin Kif25 suppresses pre-mitotic centrosome separation to establish proper spindle orientation.

Decarreau J, Wagenbach M, Lynch E, Halpern AR, Vaughan JC, Kollman J, Wordeman L. Decarreau J, et al. Nat Cell Biol. 2017 May 31;19(6):740. doi: 10.1038/ncb3546. Nat Cell Biol. 2017. PMID: 28561052 No abstract available.

5

Coupled structural transitions enable highly cooperative regulation of human CTPS2 filaments.

Lynch EM, Kollman JM. Lynch EM, et al. Nat Struct Mol Biol. 2020 Jan;27(1):42-48. doi: 10.1038/s41594-019-0352-5. Epub 2019 Dec 23. Nat Struct Mol Biol. 2020. PMID: 31873303 Free PMC article.

6

Polymerization in the actin ATPase clan regulates hexokinase activity in yeast.

Stoddard PR, Lynch EM, Farrell DP, Dosey AM, DiMaio F, Williams TA, Kollman JM, Murray AW, Garner EC. Stoddard PR, et al. Among authors: lynch em. Science. 2020 Feb 28;367(6481):1039-1042. doi: 10.1126/science.aay5359. Science. 2020. PMID: 32108112 Free PMC article.

7

Filament formation by metabolic enzymes-A new twist on regulation.

Lynch EM, Kollman JM, Webb BA. Lynch EM, et al. Curr Opin Cell Biol. 2020 Oct;66:28-33. doi: 10.1016/j.ceb.2020.04.006. Epub 2020 May 14. Curr Opin Cell Biol. 2020. PMID: 32417394 Free PMC article. Review.

8

CTP synthase polymerization in germline cells of the developing Drosophila egg supports egg production.

Simonet JC, Foster MJ, Lynch EM, Kollman JM, Nicholas E, O'Reilly AM, Peterson JR. Simonet JC, et al. Among authors: lynch em. Biol Open. 2020 Jul 21;9(7):bio050328. doi: 10.1242/bio.050328. Biol Open. 2020. PMID: 32580972 Free PMC article.

9

Computational design of transmembrane pores.

Xu C, Lu P, Gamal El-Din TM, Pei XY, Johnson MC, Uyeda A, Bick MJ, Xu Q, Jiang D, Bai H, Reggiano G, Hsia Y, Brunette TJ, Dou J, Ma D, Lynch EM, Boyken SE, Huang PS, Stewart L, DiMaio F, Kollman JM, Luisi BF, Matsuura T, Catterall WA, Baker D. Xu C, et al. Among authors: lynch em. Nature. 2020 Sep;585(7823):129-134. doi: 10.1038/s41586-020-2646-5. Epub 2020 Aug 26. Nature. 2020. PMID: 32848250 Free PMC article.

10

Structural basis for isoform-specific inhibition of human CTPS1.

Lynch EM, DiMattia MA, Albanese S, van Zundert GCP, Hansen JM, Quispe JD, Kennedy MA, Verras A, Borrelli K, Toms AV, Kaila N, Kreutter KD, McElwee JJ, Kollman JM. Lynch EM, et al. Proc Natl Acad Sci U S A. 2021 Oct 5;118(40):e2107968118. doi: 10.1073/pnas.2107968118. Proc Natl Acad Sci U S A. 2021. PMID: 34583994 Free PMC article.

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