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Page 1
An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity.
Kopper O, de Witte CJ, Lõhmussaar K, Valle-Inclan JE, Hami N, Kester L, Balgobind AV, Korving J, Proost N, Begthel H, van Wijk LM, Revilla SA, Theeuwsen R, van de Ven M, van Roosmalen MJ, Ponsioen B, Ho VWH, Neel BG, Bosse T, Gaarenstroom KN, Vrieling H, Vreeswijk MPG, van Diest PJ, Witteveen PO, Jonges T, Bos JL, van Oudenaarden A, Zweemer RP, Snippert HJG, Kloosterman WP, Clevers H. Kopper O, et al. Among authors: lohmussaar k. Nat Med. 2019 May;25(5):838-849. doi: 10.1038/s41591-019-0422-6. Epub 2019 Apr 22. Nat Med. 2019. PMID: 31011202
Patient-derived organoids model cervical tissue dynamics and viral oncogenesis in cervical cancer.
Lõhmussaar K, Oka R, Espejo Valle-Inclan J, Smits MHH, Wardak H, Korving J, Begthel H, Proost N, van de Ven M, Kranenburg OW, Jonges TGN, Zweemer RP, Veersema S, van Boxtel R, Clevers H. Lõhmussaar K, et al. Cell Stem Cell. 2021 Aug 5;28(8):1380-1396.e6. doi: 10.1016/j.stem.2021.03.012. Epub 2021 Apr 13. Cell Stem Cell. 2021. PMID: 33852917 Free article.
Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy.
Driehuis E, Kolders S, Spelier S, Lõhmussaar K, Willems SM, Devriese LA, de Bree R, de Ruiter EJ, Korving J, Begthel H, van Es JH, Geurts V, He GW, van Jaarsveld RH, Oka R, Muraro MJ, Vivié J, Zandvliet MMJM, Hendrickx APA, Iakobachvili N, Sridevi P, Kranenburg O, van Boxtel R, Kops GJPL, Tuveson DA, Peters PJ, van Oudenaarden A, Clevers H. Driehuis E, et al. Among authors: lohmussaar k. Cancer Discov. 2019 Jul;9(7):852-871. doi: 10.1158/2159-8290.CD-18-1522. Epub 2019 May 3. Cancer Discov. 2019. PMID: 31053628
Patient-Derived Ovarian Cancer Organoids Mimic Clinical Response and Exhibit Heterogeneous Inter- and Intrapatient Drug Responses.
de Witte CJ, Espejo Valle-Inclan J, Hami N, Lõhmussaar K, Kopper O, Vreuls CPH, Jonges GN, van Diest P, Nguyen L, Clevers H, Kloosterman WP, Cuppen E, Snippert HJG, Zweemer RP, Witteveen PO, Stelloo E. de Witte CJ, et al. Among authors: lohmussaar k. Cell Rep. 2020 Jun 16;31(11):107762. doi: 10.1016/j.celrep.2020.107762. Cell Rep. 2020. PMID: 32553164 Free article.
Transcriptional and epigenomic profiling identifies YAP signaling as a key regulator of intestinal epithelium maturation.
Pikkupeura LM, Bressan RB, Guiu J, Chen Y, Maimets M, Mayer D, Schweiger PJ, Hansen SL, Maciag GJ, Larsen HL, Lõhmussaar K, Pedersen MT, Teves JMY, Bornholdt J, Benes V, Sandelin A, Jensen KB. Pikkupeura LM, et al. Among authors: lohmussaar k. Sci Adv. 2023 Jul 14;9(28):eadf9460. doi: 10.1126/sciadv.adf9460. Epub 2023 Jul 12. Sci Adv. 2023. PMID: 37436997 Free PMC article.
Human-Derived Model Systems in Gynecological Cancer Research.
Lõhmussaar K, Boretto M, Clevers H. Lõhmussaar K, et al. Trends Cancer. 2020 Dec;6(12):1031-1043. doi: 10.1016/j.trecan.2020.07.007. Epub 2020 Aug 24. Trends Cancer. 2020. PMID: 32855097 Free article. Review.