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Meta-analysis of proportion estimates of Extended-Spectrum-Beta-Lactamase-producing Enterobacteriaceae in East Africa hospitals.
Sonda T, Kumburu H, van Zwetselaar M, Alifrangis M, Lund O, Kibiki G, Aarestrup FM. Sonda T, et al. Among authors: alifrangis m. Antimicrob Resist Infect Control. 2016 May 14;5:18. doi: 10.1186/s13756-016-0117-4. eCollection 2016. Antimicrob Resist Infect Control. 2016. PMID: 27186369 Free PMC article. Review.
Heterogeneity (I(2)) between countries' proportions in ESBL was significantly high (96.95 % and p < 0.001). The frequently detected genes encoding ESBL were CTX-M, TEM, SHV and OXA while the most infrequent reported genes were KPC and NDM. ...

Heterogeneity (I(2)) between countries' proportions in ESBL was significantly high (96.95 % and p < 0.001). The frequently detected genes

Prevalence and risk factors for CTX-M gram-negative bacteria in hospitalized patients at a tertiary care hospital in Kilimanjaro, Tanzania.
Sonda T, Kumburu H, van Zwetselaar M, Alifrangis M, Mmbaga BT, Lund O, Aarestrup FM, Kibiki G. Sonda T, et al. Among authors: alifrangis m. Eur J Clin Microbiol Infect Dis. 2018 May;37(5):897-906. doi: 10.1007/s10096-018-3196-8. Epub 2018 Feb 20. Eur J Clin Microbiol Infect Dis. 2018. PMID: 29464424 Free PMC article.
The prevalence of ESBL-producing gram-negative bacteria was determined based on the presence of bla(CTX-M). The odds ratio (OR) and risk factors for ESBL-producing gram-negative bacteria due to CTX-M were assessed using logistic regression models. ...The prevalence …
The prevalence of ESBL-producing gram-negative bacteria was determined based on the presence of bla(CTX-M). The odds ratio (OR) and r …
Prevalence of asymptomatic malaria, submicroscopic parasitaemia and anaemia in Korogwe District, north-eastern Tanzania.
Hayuma PM, Wang CW, Liheluka E, Baraka V, Madebe RA, Minja DTR, Misinzo G, Alifrangis M, Lusingu JPA. Hayuma PM, et al. Among authors: alifrangis m. Malar J. 2021 Oct 29;20(1):424. doi: 10.1186/s12936-021-03952-3. Malar J. 2021. PMID: 34715886 Free PMC article.
The study assessed the prevalence of submicroscopic asymptomatic malaria infections and anaemia in two rural low (300 m above sea level) and highland (700 m asl) settings of Korogwe District north-eastern Tanzania. ...
The study assessed the prevalence of submicroscopic asymptomatic malaria infections and anaemia in two rural low (300 m above sea lev …
Neoadjuvant Platinum-Based chemotherapy and lymphadenectomy for penile cancer: an international, Multi-Institutional, Real-World study.
Rose KM, Pham R, Zacharias NM, Ionescu F, Paravathaneni M, Marchetti KA, Sanchez D, Mustasam A, Sandstrom R, Vikram R, Dhillon J, Rao P, Schneider A, Pagliaro L, Alifrangis C, Albersen M, Roussel E, Master VA, Nazha B, Hernandez C, Moses KA, Protzel C, Montgomery J, Angel M, Tobias-Machado M, Spiess PE, Pettaway CA, Chahoud J. Rose KM, et al. Among authors: alifrangis c. J Natl Cancer Inst. 2024 Feb 16:djae034. doi: 10.1093/jnci/djae034. Online ahead of print. J Natl Cancer Inst. 2024. PMID: 38366627
In vitro CYP450 enzyme down-regulation by GLP-1/glucagon co-agonist does not translate to observed drug-drug interactions in the clinic.
Säll C, Alifrangis L, Dahl K, Friedrichsen MH, Nygård SB, Kristensen K. Säll C, et al. Among authors: alifrangis l. Drug Metab Dispos. 2022 Jun 9:DMD-AR-2022-000865. doi: 10.1124/dmd.122.000865. Online ahead of print. Drug Metab Dispos. 2022. PMID: 35680133 Free article.
To investigate the clinical relevance of observed in vitro CYP down-regulation, a phase 1 clinical cocktail study was initiated to assess the DDI potential. The study enrolled 45 study participants (BMI 23.0-29.9 kg/m(2)) to receive a Cooperstown 5+1 cocktail (midazolam, c …
To investigate the clinical relevance of observed in vitro CYP down-regulation, a phase 1 clinical cocktail study was initiated to assess th …
EMA/CO for high-risk gestational trophoblastic neoplasia: good outcomes with induction low-dose etoposide-cisplatin and genetic analysis.
Alifrangis C, Agarwal R, Short D, Fisher RA, Sebire NJ, Harvey R, Savage PM, Seckl MJ. Alifrangis C, et al. J Clin Oncol. 2013 Jan 10;31(2):280-6. doi: 10.1200/JCO.2012.43.1817. Epub 2012 Dec 10. J Clin Oncol. 2013. PMID: 23233709
Genetic analysis identified nongestational trophoblastic tumors (nGTTs). The use of induction low-dose etoposide 100 mg/m(2) and cisplatin 20 mg/m(2) (EP; days 1 and 2 every 7 days) since 1995 to reduce early deaths before commencing EMA/CO was noted. ...
Genetic analysis identified nongestational trophoblastic tumors (nGTTs). The use of induction low-dose etoposide 100 mg/m(2) and cisp …
Molecular epidemiology of virulence and antimicrobial resistance determinants in Klebsiella pneumoniae from hospitalised patients in Kilimanjaro, Tanzania.
Sonda T, Kumburu H, van Zwetselaar M, Alifrangis M, Mmbaga BT, Lund O, Kibiki GS, Aarestrup FM. Sonda T, et al. Among authors: alifrangis m. Eur J Clin Microbiol Infect Dis. 2018 Oct;37(10):1901-1914. doi: 10.1007/s10096-018-3324-5. Epub 2018 Jul 20. Eur J Clin Microbiol Infect Dis. 2018. PMID: 30030694
K. pneumoniae ST17 were 6 (17.6%). The commonest determinants were bla(CTX-M-15) in 16 (47.1%) isolates(,) bla(SHV) in 30 (88.2%), bla(OXA-1) in 8 (23.5%) and bla(TEM-1) in 18 (52.9%) isolates. ...
K. pneumoniae ST17 were 6 (17.6%). The commonest determinants were bla(CTX-M-15) in 16 (47.1%) isolates(,) bla(SHV) in 30 (88.2%), bl …
Associations between alpha+-thalassemia and Plasmodium falciparum malarial infection in northeastern Tanzania.
Enevold A, Alifrangis M, Sanchez JJ, Carneiro I, Roper C, Børsting C, Lusingu J, Vestergaard LS, Lemnge MM, Morling N, Riley E, Drakeley CJ. Enevold A, et al. Among authors: alifrangis m. J Infect Dis. 2007 Aug 1;196(3):451-9. doi: 10.1086/519390. Epub 2007 Jun 20. J Infect Dis. 2007. PMID: 17597460
RESULTS: The frequency of alpha (+)-thalassemia ranged from 10%-25% in high-altitude villages (>1200 m) to 45%-55% in low-altitude villages (<600 m). The carriage rate of alpha (+)-thalassemia decreased by approximately 12% per 100-m increase in altitud …
RESULTS: The frequency of alpha (+)-thalassemia ranged from 10%-25% in high-altitude villages (>1200 m) to 45%-55% in low-altitude …
14 results