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Year Number of Results
1980 1
1981 2
1982 1
1986 5
1987 4
1988 2
1989 5
1990 13
1991 8
1992 9
1993 16
1994 17
1995 23
1996 20
1997 23
1998 22
1999 30
2000 25
2001 36
2002 56
2003 79
2004 73
2005 86
2006 114
2007 112
2008 168
2009 148
2010 185
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2017 479
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2021 934
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2024 379

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8,253 results

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Page 1
QKI shuttles internal m(7)G-modified transcripts into stress granules and modulates mRNA metabolism.
Zhao Z, Qing Y, Dong L, Han L, Wu D, Li Y, Li W, Xue J, Zhou K, Sun M, Tan B, Chen Z, Shen C, Gao L, Small A, Wang K, Leung K, Zhang Z, Qin X, Deng X, Xia Q, Su R, Chen J. Zhao Z, et al. Among authors: dong l. Cell. 2023 Jul 20;186(15):3208-3226.e27. doi: 10.1016/j.cell.2023.05.047. Epub 2023 Jun 27. Cell. 2023. PMID: 37379838
Although m(7)G-cap is essential for pre-mRNA processing and protein synthesis, the exact role of mRNA internal m(7)G modification remains elusive. Here, we report that mRNA internal m(7)G is selectively recognized by Quaking proteins (QKIs). By transcriptome- …
Although m(7)G-cap is essential for pre-mRNA processing and protein synthesis, the exact role of mRNA internal m(7)G modificat …
Ferroptosis Enhanced Diabetic Renal Tubular Injury via HIF-1α/HO-1 Pathway in db/db Mice.
Feng X, Wang S, Sun Z, Dong H, Yu H, Huang M, Gao X. Feng X, et al. Among authors: dong h. Front Endocrinol (Lausanne). 2021 Feb 18;12:626390. doi: 10.3389/fendo.2021.626390. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 33679620 Free PMC article.
METHODS: Db/db mice were administered with or without ferroptosis inhibitor Ferrostatin-1 treatment, and were compared with db/m mice. RESULTS: Db/db mice showed higher urinary albumin-to-creatinine ratio (UACR) than db/m mice, and Ferrostatin-1 reduced UACR in db/d …
METHODS: Db/db mice were administered with or without ferroptosis inhibitor Ferrostatin-1 treatment, and were compared with db/m mice …
Dynamic control of chromatin-associated m(6)A methylation regulates nascent RNA synthesis.
Xu W, He C, Kaye EG, Li J, Mu M, Nelson GM, Dong L, Wang J, Wu F, Shi YG, Adelman K, Lan F, Shi Y, Shen H. Xu W, et al. Among authors: dong l. Mol Cell. 2022 Mar 17;82(6):1156-1168.e7. doi: 10.1016/j.molcel.2022.02.006. Epub 2022 Feb 25. Mol Cell. 2022. PMID: 35219383 Free PMC article.
N(6)-methyladenosine (m(6)A) methylation is co-transcriptionally deposited on mRNA, but a possible role of m(6)A on transcription remains poorly understood. ...Consistently, we found the Integrator complex component INTS11 elevated at promoters and enhancers upon lo …
N(6)-methyladenosine (m(6)A) methylation is co-transcriptionally deposited on mRNA, but a possible role of m(6)A on transcript …
Transcriptome-wide Mapping of Internal N7-Methylguanosine Methylome in Mammalian mRNA.
Zhang LS, Liu C, Ma H, Dai Q, Sun HL, Luo G, Zhang Z, Zhang L, Hu L, Dong X, He C. Zhang LS, et al. Among authors: dong x. Mol Cell. 2019 Jun 20;74(6):1304-1316.e8. doi: 10.1016/j.molcel.2019.03.036. Epub 2019 Apr 25. Mol Cell. 2019. PMID: 31031084 Free PMC article.
Here, we show the presence of internal m(7)G sites within mammalian mRNA. We then performed transcriptome-wide profiling of internal m(7)G methylome using m(7)G-MeRIP sequencing (MeRIP-seq). ...This base-resolution m(7)G-seq enabled transcriptome-wide …
Here, we show the presence of internal m(7)G sites within mammalian mRNA. We then performed transcriptome-wide profiling of internal …
Mettl3-mediated mRNA m(6)A modification controls postnatal liver development by modulating the transcription factor Hnf4a.
Xu Y, Zhou Z, Kang X, Pan L, Liu C, Liang X, Chu J, Dong S, Li Y, Liu Q, Sun Y, Yu S, Zhang Q. Xu Y, et al. Among authors: dong s. Nat Commun. 2022 Aug 5;13(1):4555. doi: 10.1038/s41467-022-32169-4. Nat Commun. 2022. PMID: 35931692 Free PMC article.
However, the function of m(6)A in liver development remains elusive. Here we dissect the role of Mettl3-mediated m(6)A modification in postnatal liver development and homeostasis. Knocking out Mettl3 perinatally with Alb-Cre (Mettl3 cKO) induces apoptosis and steato …
However, the function of m(6)A in liver development remains elusive. Here we dissect the role of Mettl3-mediated m(6)A modific …
METTL3/METTL14 Transactivation and m(6)A-Dependent TGF-beta1 Translation in Activated Kupffer Cells.
Feng Y, Dong H, Sun B, Hu Y, Yang Y, Jia Y, Jia L, Zhong X, Zhao R. Feng Y, et al. Among authors: dong h. Cell Mol Gastroenterol Hepatol. 2021;12(3):839-856. doi: 10.1016/j.jcmgh.2021.05.007. Epub 2021 May 13. Cell Mol Gastroenterol Hepatol. 2021. PMID: 33992834 Free PMC article.
RNA-sequencing and m(6)A-seq were employed to screen differentially expressed genes and responsive m(6)A peaks. ...CONCLUSIONS: NF-kappaB acts as transcription factor to transactivate METTL3/METTL14 genes upon LPS challenge, leading to global RNA m(6)A hyperm …
RNA-sequencing and m(6)A-seq were employed to screen differentially expressed genes and responsive m(6)A peaks. ...CONCLUSIONS …
The m(6)A methyltransferase Mettl3 deficiency attenuates hepatic stellate cell activation and liver fibrosis.
Li Y, Kang X, Zhou Z, Pan L, Chen H, Liang X, Chu J, Dong S, Liu C, Yu S, Tu D, Zhang Y, Ge M, Chen W, Xu Y, Zhang Q. Li Y, et al. Among authors: dong s. Mol Ther. 2022 Dec 7;30(12):3714-3728. doi: 10.1016/j.ymthe.2022.07.020. Epub 2022 Aug 2. Mol Ther. 2022. PMID: 35923112 Free PMC article.
However, the functional role of Mettl3-mediated m(6)A in liver fibrosis remains elusive. Here, we found that the HSC-specific knockout of m(6)A methyltransferase Mettl3 suppressed HSC activation and significantly alleviated liver fibrosis. Multi-omics analysis of HS …
However, the functional role of Mettl3-mediated m(6)A in liver fibrosis remains elusive. Here, we found that the HSC-specific knockou …
Mycobacterium bovis induces mitophagy to suppress host xenophagy for its intracellular survival.
Song Y, Ge X, Chen Y, Hussain T, Liang Z, Dong Y, Wang Y, Tang C, Zhou X. Song Y, et al. Among authors: dong y. Autophagy. 2022 Jun;18(6):1401-1415. doi: 10.1080/15548627.2021.1987671. Epub 2021 Oct 31. Autophagy. 2022. PMID: 34720021 Free PMC article.
M. bovis is the causative agent of animal tuberculosis and human tuberculosis. In the current study, we show that M. bovis induces mitophagy in macrophages, and the induction of mitophagy is impaired by PINK1 knockdown, indicating the PINK1-PRKN/Parkin pathway is in
M. bovis is the causative agent of animal tuberculosis and human tuberculosis. In the current study, we show that M. bovis ind
FTO suppresses glycolysis and growth of papillary thyroid cancer via decreasing stability of APOE mRNA in an N6-methyladenosine-dependent manner.
Huang J, Sun W, Wang Z, Lv C, Zhang T, Zhang D, Dong W, Shao L, He L, Ji X, Zhang P, Zhang H. Huang J, et al. Among authors: dong w. J Exp Clin Cancer Res. 2022 Jan 28;41(1):42. doi: 10.1186/s13046-022-02254-z. J Exp Clin Cancer Res. 2022. PMID: 35090515 Free PMC article.
However, dysregulation of m(6)A modification and effect of m(6)A demethylase fat-mass and obesity-associated protein (FTO) on glucose metabolism has not been fully elucidated in papillary thyroid cancer (PTC). ...FTO knockdown significantly increased APOE mRNA m
However, dysregulation of m(6)A modification and effect of m(6)A demethylase fat-mass and obesity-associated protein (FTO) on …
m(5)C-dependent cross-regulation between nuclear reader ALYREF and writer NSUN2 promotes urothelial bladder cancer malignancy through facilitating RABL6/TK1 mRNAs splicing and stabilization.
Wang N, Chen RX, Deng MH, Wei WS, Zhou ZH, Ning K, Li YH, Li XD, Ye YL, Wen JH, Dong B, Zhang XP, Liu ZW, Zhou FJ. Wang N, et al. Among authors: dong b. Cell Death Dis. 2023 Feb 18;14(2):139. doi: 10.1038/s41419-023-05661-y. Cell Death Dis. 2023. PMID: 36806253 Free PMC article.
The significance of 5-methylcytosine (m(5)C) methylation in human malignancies has become an increasing focus of investigation. ...Our study unveils an m(5)C dependent cross-regulation between nuclear reader ALYREF and m(5)C writer NSUN2 in activation of hype …
The significance of 5-methylcytosine (m(5)C) methylation in human malignancies has become an increasing focus of investigation. ...Ou …
8,253 results